Journal article
Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States
Journal of the American Heart Association, Vol.8(3), pp.e010995-e010995
02/05/2019
DOI: 10.1161/JAHA.118.010995
PMCID: PMC6405581
PMID: 30696385
Abstract
Background More intense and longer-lasting heat events are expected in the United States as a consequence of climate change. This study aimed to project the potential changes in maternal heat exposure during early pregnancy (3-8 weeks post conception) and the associated burden of congenital heart defects ( CHD s) in the future. Methods and Results This study expanded on a prior nationwide case-control study that evaluated the association between CHD s and maternal heat exposure during early pregnancy in summer and spring. We defined multiple indicators of heat exposure, and applied published odds ratios obtained for the matching season of the baseline (1995-2005) into the projection period (2025-2035) to estimate potential changes in CHD burden throughout the United States. Increases in maternal heat exposure were projected across the United States and to be larger in the summer. The Midwest will potentially have the highest increase in summer maternal exposure to excessively hot days (3.42; 95% CI, 2.99-3.88 per pregnancy), heat event frequency (0.52; 95% CI, 0.44-0.60) and heat event duration (1.73; 95% CI, 1.49-1.97). We also found large increases in specific CHD subtypes during spring, including a 34.0% (95% CI, 4.9%-70.8%) increase in conotruncal CHD in the South and a 38.6% (95% CI , 9.9%-75.1%) increase in atrial septal defect in the Northeast. Conclusions Projected increases in maternal heat exposure could result in an increased CHD burden in certain seasons and regions of the United States.
Details
- Title: Subtitle
- Projected Changes in Maternal Heat Exposure During Early Pregnancy and the Associated Congenital Heart Defect Burden in the United States
- Creators
- Wangjian Zhang - 2 Department of Environmental Health Sciences University at Albany, State University of New York Rensselaer NYTanya L Spero - 4 National Exposure Research Laboratory U.S. Environmental Protection Agency Research Triangle Park NCChristopher G Nolte - 4 National Exposure Research Laboratory U.S. Environmental Protection Agency Research Triangle Park NCValerie C Garcia - 4 National Exposure Research Laboratory U.S. Environmental Protection Agency Research Triangle Park NCZiqiang Lin - 5 Department of Mathematics University at Albany NYPaul A Romitti - 6 Department of Epidemiology University of Iowa Iowa City IAGary M Shaw - 7 Stanford University School of Medicine Stanford CAScott C Sheridan - 8 Department of Geography Kent State University Kent OHMarcia L Feldkamp - 9 University of Utah School of Medicine Salt Lake City UTAlison Woomert - 10 University of North Carolina Chapel Hill NCSyni-An Hwang - 11 New York State Department of Health Albany NYSarah C Fisher - 11 New York State Department of Health Albany NYMarilyn L Browne - 11 New York State Department of Health Albany NYYuantao Hao - 1 Department of Medical Statistics and Epidemiology School of Public Health Sun Yat-sen University Guangzhou ChinaShao Lin - 2 Department of Environmental Health Sciences University at Albany, State University of New York Rensselaer NYNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.8(3), pp.e010995-e010995
- Publisher
- England
- DOI
- 10.1161/JAHA.118.010995
- PMID
- 30696385
- PMCID
- PMC6405581
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Grant note
- P30 ES005605 / NIEHS NIH HHS U38 EH000184 / NCEH CDC HHS U01 DD001226 / NCBDD CDC HHS U01 DD001035 / NCBDD CDC HHS U01 DD001223 / NCBDD CDC HHS
- Language
- English
- Date published
- 02/05/2019
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983996097002771
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