Projection targets of medial frontal D1DR-expressing neurons

Sang-Woo Han; Young-Cho Kim; Nandakumar S Narayanan

doi:10.1016/j.neulet.2017.06.057

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Projection targets of medial frontal D1DR-expressing neurons

Journal article

Peer reviewed

Projection targets of medial frontal D1DR-expressing neurons

Sang-Woo Han, Young-Cho Kim and Nandakumar S Narayanan

Neuroscience letters, Vol.655, pp.166-171

08/10/2017

DOI: 10.1016/j.neulet.2017.06.057

PMCID: PMC5568680

PMID: 28689051

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https://www.ncbi.nlm.nih.gov/pmc/articles/5568680View

Open Access

Abstract

Prefrontal neurons expressing D1-type dopamine receptors (D1DRs) have been implicated in a variety of cognitive processes including working memory and timing. Although D1DRs are most strongly expressed on layer V/VI projection neurons, it is unknown which brain areas are specifically targeted by these projections. Here we selectively marked D1DR neurons using cre-loxP techniques with AAV carrying mCherry fluorescent protein, and traced projection targets of D1DR+ neurons in the mouse medial frontal cortex (MFC). We found relatively strong MFC D1DR+ projections to cortical areas as well as projections to basal ganglia and thalamic nuclei. We found relatively weaker MFC D1DR+ projections to the brainstem, hypothalamus, and other subcortical nuclei. These data intimate that MFC D1DR+ projections are well-positioned to powerfully influence cortical processing and have subcortical specificity. Thus MFC D1DR+ projection neurons may play a key role in tuning cortical networks during goal-directed behavior.

Animals

Thalamus - physiology

Neurons - physiology

Cerebral Cortex - physiology

Mice, Transgenic

Basal Ganglia - physiology

Brain Stem - physiology

Frontal Lobe - physiology

Receptors, Dopamine D1 - genetics

Receptors, Dopamine D1 - metabolism

Details

Title: Subtitle: Projection targets of medial frontal D1DR-expressing neurons
Creators: Sang-Woo Han - Department of Neurology, University of Iowa, Iowa City, IA, 52242, United States
Young-Cho Kim - Department of Neurology, University of Iowa, Iowa City, IA, 52242, United States
Nandakumar S Narayanan - Department of Neurology, University of Iowa, Iowa City, IA, 52242, United States. Electronic address: Nandakumar-narayanan@uiowa.edu
Resource Type: Journal article
Publication Details: Neuroscience letters, Vol.655, pp.166-171
DOI: 10.1016/j.neulet.2017.06.057
PMID: 28689051
PMCID: PMC5568680
NLM abbreviation: Neurosci Lett
ISSN: 0304-3940
eISSN: 1872-7972
Publisher: Ireland
Grant note: R01 NS089470 / NINDS NIH HHS
Language: English
Date published: 08/10/2017
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070984302771

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