Prolactin secretion in hypothyroid endotoxemic rats: Involvement of L-arginine and nitric oxide synthase

Tania T Rodriguez; Eduardo F. S Biscarde; Relva F. D. G Muniz; Mauricio K Amoedo; Maria José Ramalho

doi:10.1097/01.shk.0000160938.08385.b8

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Prolactin secretion in hypothyroid endotoxemic rats: Involvement of L-arginine and nitric oxide synthase

Journal article

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Peer reviewed

Prolactin secretion in hypothyroid endotoxemic rats: Involvement of L-arginine and nitric oxide synthase

Tania T Rodriguez, Eduardo F. S Biscarde, Relva F. D. G Muniz, Mauricio K Amoedo and Maria José Ramalho

Shock (Augusta, Ga.), Vol.23(5), pp.448-452

05/01/2005

DOI: 10.1097/01.shk.0000160938.08385.b8

PMID: 15834311

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Abstract

The identification of nitric oxide (NO) within the hypothalamus and pituitary gland has suggested its role as modulator of the activity on hypothalamic-pituitary axis. Hypothalamic NO synthase (NOS) is known to be regulated by thyroid hormones. We investigated the effects of previous injection of Nϖ-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, and L-arginine (L-Arg), the substrate for NO synthesis, on prolactin (PRL) secretion, through the lipopolysaccharide (LPS)-induced inflammatory response in thyroidectomized (TX) rats. TX or sham-operated (N) rats were intraperitoneally (i.p.) injected with L-NAME (10 mg kg-1) or L-Arg (200 mg kg-1) or the same volume of vehicle (saline solution) 30 min before endotoxemia-induction with LPS at 250 μg (100 g body weight)-1, i.p.. In N rats, NO increased PRL release in response to endotoxemia, whereas in hypothyroid rats, NO appeared to have the opposite effect. Our data support the hypothesis that NO exerts a modulatory influence on PRL secretion after LPS-induced inflammatory response.

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Biological and medical sciences

Blood and lymphatic vessels

Cardiology. Vascular system

Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous

Intensive care medicine

Liver, biliary tract, pancreas, portal circulation, spleen

Medical sciences

Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases

Surgery of the digestive system

Details

Title: Subtitle: Prolactin secretion in hypothyroid endotoxemic rats: Involvement of L-arginine and nitric oxide synthase
Creators: Tania T Rodriguez - Universidade Federal da Bahia
Eduardo F. S Biscarde - Anesthesia and Intensive Care Unit, Sao Rafael Hospital, 41256-900 Salvador, Bahia, Brazil
Relva F. D. G Muniz - Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100 Bahia, Brazil
Mauricio K Amoedo - Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100 Bahia, Brazil
Maria José Ramalho - Department of Physiology, Health Sciences Center, Federal University of Bahia, 40110-100 Bahia, Brazil
Resource Type: Journal article
Publication Details: Shock (Augusta, Ga.), Vol.23(5), pp.448-452
Publisher: BioMedical Press
DOI: 10.1097/01.shk.0000160938.08385.b8
PMID: 15834311
ISSN: 1073-2322
eISSN: 1540-0514
Language: English
Date published: 05/01/2005
Academic Unit: Radiology
Record Identifier: 9984697637802771

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