Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection

Erika L Wissinger; Whitney W Stevens; Steven M Varga; Thomas J Braciale

doi:10.4049/jimmunol.180.5.2957

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Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection

Journal article

Peer reviewed

Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection

Erika L Wissinger, Whitney W Stevens, Steven M Varga and Thomas J Braciale

The Journal of immunology (1950), Vol.180(5), pp.2957-2966

03/01/2008

DOI: 10.4049/jimmunol.180.5.2957

PMCID: PMC2855534

PMID: 18292518

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Abstract

The memory CD4+ T cell response to the respiratory syncytial virus (RSV) attachment (G) protein in the lungs of primed BALB/c mice undergoing challenge pulmonary RSV infection is dominated by effector T cells expressing a single Vbeta-chain, Vbeta14. We have used Vbeta14 expression to examine the kinetics of the activation, accumulation, and acquisition of the effector activity of memory CD4+ T cells responding to pulmonary infection. This analysis revealed that proliferative expansion and effector CD4+ T cell differentiation preferentially occur in the respiratory tract following rapid activation within and egress from the lymph nodes draining the respiratory tract. These findings suggest that, in response to natural infection at a peripheral mucosal site such as the lungs, memory CD4+ T cell expansion and differentiation into activated effector T cells may occur predominantly in the peripheral site of infection rather than exclusively in the lymph nodes draining the site of infection.

Animals

CD4-Positive T-Lymphocytes - immunology

CD4-Positive T-Lymphocytes - metabolism

CD4-Positive T-Lymphocytes - pathology

CD4-Positive T-Lymphocytes - virology

Cell Movement - immunology

Cell Proliferation

Epitopes, T-Lymphocyte - immunology

Female

Genetic Vectors

Immunologic Memory

Kinetics

Lung - immunology

Lung - pathology

Lung - virology

Mice

Mice, Inbred BALB C

Respiratory Syncytial Virus Infections - immunology

Respiratory Syncytial Virus Infections - metabolism

Respiratory Syncytial Virus Infections - pathology

Respiratory Syncytial Viruses - genetics

Respiratory Syncytial Viruses - immunology

Vaccinia virus - genetics

Vaccinia virus - immunology

Viral Envelope Proteins - administration & dosage

Viral Envelope Proteins - genetics

Viral Envelope Proteins - immunology

Details

Title: Subtitle: Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection
Creators: Erika L Wissinger - The Carter Immunology Center, Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
Whitney W Stevens
Steven M Varga - University of Iowa, Microbiology and Immunology
Thomas J Braciale
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.180(5), pp.2957-2966
DOI: 10.4049/jimmunol.180.5.2957
PMID: 18292518
PMCID: PMC2855534
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: R01 HL033391-19 / NHLBI NIH HHS R01 AI037293-11 / NIAID NIH HHS R01 HL033391-22 / NHLBI NIH HHS R01 HL033391-27 / NHLBI NIH HHS R01 AI037293-14 / NIAID NIH HHS R01 HL033391-24 / NHLBI NIH HHS R01 AI015608-27 / NIAID NIH HHS R01 AI015608 / NIAID NIH HHS T32 AI007046 / NIAID NIH HHS T32 AI07496 / NIAID NIH HHS HL33391 / NHLBI NIH HHS AI15608 / NIAID NIH HHS R01 AI015608-25 / NIAID NIH HHS AI37293 / NIAID NIH HHS R01 AI037293-10 / NIAID NIH HHS R01 HL071875-04 / NHLBI NIH HHS R01 AI037293-13 / NIAID NIH HHS R01 AI037293 / NIAID NIH HHS R01 AI015608-28 / NIAID NIH HHS R01 AI037293-12 / NIAID NIH HHS R01 HL033391-21 / NHLBI NIH HHS T32 GM007267 / NIGMS NIH HHS R01 HL033391 / NHLBI NIH HHS R01 AI037293-09 / NIAID NIH HHS R01 HL033391-20 / NHLBI NIH HHS R01 HL071875 / NHLBI NIH HHS R01 HL033391-18 / NHLBI NIH HHS R01 HL033391-23 / NHLBI NIH HHS R01 AI015608-26 / NIAID NIH HHS R01 AI015608-29 / NIAID NIH HHS T32 AI007496 / NIAID NIH HHS R37 AI015608 / NIAID NIH HHS
Language: English
Date published: 03/01/2008
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984210532702771

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