Prolonged Reactive Oxygen Species Production following Septic Insult

Isaac J Jensen; Patrick W McGonagill; Roger R Berton; Brett A Wagner; Elvia E Silva; Garry R Buettner; Thomas S Griffith; Vladimir P Badovinac

doi:10.4049/immunohorizons.2100027

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Prolonged Reactive Oxygen Species Production following Septic Insult

Journal article

Open access

Peer reviewed

Prolonged Reactive Oxygen Species Production following Septic Insult

Isaac J Jensen, Patrick W McGonagill, Roger R Berton, Brett A Wagner, Elvia E Silva, Garry R Buettner, Thomas S Griffith and Vladimir P Badovinac

ImmunoHorizons, Vol.5(6), pp.477-488

06/18/2021

DOI: 10.4049/immunohorizons.2100027

PMID: 34145054

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Abstract

The dysregulated host response and organ damage following systemic infection that characterizes a septic event predisposes individuals to a chronic immunoparalysis state associated with severe transient lymphopenia and diminished lymphocyte function, thereby reducing long-term patient survival and quality of life. Recently, we observed lasting production of reactive oxygen species (ROS) in mice that survive sepsis. ROS production is a potent mechanism for targeting infection, but excessive ROS production can prove maladaptive by causing organ damage, impairing lymphocyte function, and promoting inflammaging, concepts paralleling sepsis-induced immunoparalysis. Notably, we observed an increased frequency of ROS-producing immature monocytes in septic hosts that was sustained for greater than 100 days postsurgery. Recent clinical trials have explored the use of vitamin C, a potent antioxidant, for treating septic patients. We observed that therapeutic vitamin C administration for sepsis limited ROS production by monocytes and reduced disease severity. Importantly, we also observed increased ROS production by immature monocytes in septic patients both at admission and ∼28 days later, suggesting a durable and conserved feature that may influence the host immune response. Thus, lasting ROS production by immature monocytes is present in septic patients, and early intervention strategies to reduce it may improve host outcomes, potentially reducing sepsis-induced immunoparalysis. Copyright © 2021 The Authors.

Details

Title: Subtitle: Prolonged Reactive Oxygen Species Production following Septic Insult
Creators: Isaac J Jensen - University of Iowa
Patrick W McGonagill - University of Iowa
Roger R Berton - University of Iowa
Brett A Wagner - University of Iowa
Elvia E Silva - University of Iowa
Garry R Buettner - University of Iowa
Thomas S Griffith - University of Minnesota
Vladimir P Badovinac - University of Iowa
Resource Type: Journal article
Publication Details: ImmunoHorizons, Vol.5(6), pp.477-488
DOI: 10.4049/immunohorizons.2100027
PMID: 34145054
NLM abbreviation: Immunohorizons
ISSN: 2573-7732
eISSN: 2573-7732
Language: English
Date published: 06/18/2021
Academic Unit: Microbiology and Immunology; Pathology; Surgery; Radiation Oncology; Internal Medicine
Record Identifier: 9984181065802771

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