Journal article
Prolonged coronary artery occlusion—reperfusion sequences reduce myocardial free radical production: An electron paramagnetic resonance study
The American heart journal, Vol.132(6), pp.1147-1155
1996
DOI: 10.1016/S0002-8703(96)90457-3
PMID: 8969565
Abstract
Our purpose was to determine whether prolonged myocardial ischemia attenuates free radical production after early reperfusion. Twenty-two mongrel dogs underwent left anterior descending coronary artery occlusion for 20, 40, or 60 minutes followed by 30 minutes of reperfusion. Electron paramagnetic resonance spectroscopy was used to measure ascorbate free radical in the coronary vein effluent. Ascorbate free radical production during reperfusion was significantly (
p < 0.05) reduced in the dogs undergoing 60 minutes of coronary artery occlusion compared with the dogs undergoing 40 and 20 minutes of occlusion. We conclude that prolonged myocardial ischemia results in less free radical production on reperfusion than do shorter periods of ischemia followed by reperfusion.
Details
- Title: Subtitle
- Prolonged coronary artery occlusion—reperfusion sequences reduce myocardial free radical production: An electron paramagnetic resonance study
- Creators
- Paul D LindowerKirk T SpencerMatthew R CaterineMukesh K SharmaGarry R BuettnerRichard E Kerber
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.132(6), pp.1147-1155
- Publisher
- Mosby, Inc
- DOI
- 10.1016/S0002-8703(96)90457-3
- PMID
- 8969565
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Cardiovascular Medicine; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984047761102771
Metrics
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