Journal article
Prolonged duration of early antibiotic therapy in extremely premature infants
Pediatric research, Vol.85(7), pp.994-1000
06/01/2019
DOI: 10.1038/s41390-019-0300-4
PMCID: PMC6531328
PMID: 30737489
Abstract
BACKGROUND: Prolonged early antibiotics in extremely premature infants may have negative effects. We aimed to assess prevalence and outcomes of provision of prolonged early antibiotics to extremely premature infants in the absence of culture-confirmed infection or NEC.
METHODS: Cohort study of infants from 13 centers born without a major birth defect from 2008-2014 who were 401-1000 grams birth weight, 22-28 weeks gestation, and survived >= 5 days without culture-confirmed infection, NEC, or spontaneous intestinal perforation. We determined the proportion of infants who received prolonged early antibiotics, defined as >= 5 days of antibiotic therapy started at <= 72 h of age, by center and over time. Associations between prolonged early antibiotics and adverse outcomes were assessed using multivariable logistic regression.
RESULTS: A total of 5730 infants were included. The proportion of infants receiving prolonged early antibiotics varied from 30-69% among centers and declined from 49% in 2008 to 35% in 2014. Prolonged early antibiotics was not significantly associated with death (adjusted odds ratio 1.17 [95% CI: 0.99-1.40], p = 0.07) and was not associated with NEC.
CONCLUSIONS: The proportion of extremely premature infants receiving prolonged early antibiotics decreased, but significant center variation persists. Prolonged early antibiotics were not significantly associated with increased odds of death or NEC.
Details
- Title: Subtitle
- Prolonged duration of early antibiotic therapy in extremely premature infants
- Creators
- Rachel G. Greenberg - Duke UniversityDhuly Chowdhury - RTI (United States)Nellie Hansen - RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USAP. Brian Smith - Duke UniversityBarbara J. Stoll - The University of Texas Health Science Center at HoustonPablo J. Sanchez - Nationwide Childrens Hosp, Dept Pediat, Columbus, OH USAAbhik Das - RTI Int, Social Stat & Environm Sci Unit, Rockville, MD USAKaren M. Puopolo - University of PennsylvaniaSagori Mukhopadhyay - University of PennsylvaniaRosemary D. Higgins - Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USAC. Michael Cotten - Duke UniversityMichael S. Caplan - University of ChicagoRichard A. Polin - Columbia UniversityAbbot R. Laptook - Brown UniversityMartin Keszler - Brown UniversityAngelita M. Hensman - Brown UniversityKristin M. Basso - Brown UniversityElisa Vieira - Brown UniversityEmily Little - Brown UniversityMichele C. Walsh - Case Western Reserve UniversityAvroy A. Fanaroff - Case Western Reserve UniversityAnna Marie Hibbs - Case Western Reserve UniversityNancy S. Newman - Case Western Reserve UniversityBonnie S. Siner - Case Western Reserve UniversityWilliam E. Truog - University of MissouriHoward W. Kilbride - University of MissouriEugenia K. Pallotto - University of MissouriCheri Gauldin - University of MissouriAnne Holmes - University of MissouriKathy Johnson - University of MissouriAllison Knutson - University of MissouriBrenda B. Poindexter - Cincinnati Children's Hospital Medical CenterKurt Schibler - Cincinnati Children's Hospital Medical CenterBarbara Alexander - Cincinnati Children's Hospital Medical CenterCathy Grisby - Cincinnati Children's Hospital Medical CenterLenora D. Jackson - Cincinnati Children's Hospital Medical CenterKristin Kirker - Cincinnati Children's Hospital Medical CenterGreg Muthig - Cincinnati Children's Hospital Medical CenterRonald N. Goldberg - Duke UniversityKimberley A. Fisher - Duke UniversitySandra Grimes - Duke UniversityJoanne Finkle - Duke UniversityMatthew M. Laughon - Duke UniversityCarl L. Bose - Duke UniversityJanice Bernhardt - Duke UniversityGennie Bose - Duke UniversityDavid P. Carlton - Emory UniversityEllen C. Hale - Emory UniversityAnn Blackwelder - Emory UniversityYvonne C. Loggins - Emory UniversityDiane Bottcher - Emory UniversityStephanie Wilson Archer - Emory UniversityGregory M. Sokol - Indiana UniversityLeslie Dawn Wilson - Indiana UniversityDianne E. Herron - Indiana UniversityKathleen A. Kennedy - The University of Texas Health Science Center at HoustonJon E. Tyson - The University of Texas Health Science Center at HoustonJulie Arldt-McAlister - The University of Texas Health Science Center at HoustonKatrina Burson - The University of Texas Health Science Center at HoustonCarmen Garcia - The University of Texas Health Science Center at HoustonBeverly Foley Harris - The University of Texas Health Science Center at HoustonKaren Martin - The University of Texas Health Science Center at HoustonSara C. Martin - The University of Texas Health Science Center at HoustonGeorgia E. McDavid - The University of Texas Health Science Center at HoustonShawna Rodgers - The University of Texas Health Science Center at HoustonPatti L. Pierce Tate - The University of Texas Health Science Center at HoustonSharon L. Wright - The University of Texas Health Science Center at HoustonLeif D. Nelin - Nationwide Childrens Hosp, Columbus, OH USASudarshan R. Jadcherla - Nationwide Childrens Hosp, Columbus, OH USAPatricia Luzader - Nationwide Childrens Hosp, Columbus, OH USAChristine A. Fortney - Nationwide Childrens Hosp, Columbus, OH USAGail E. Besner - Nationwide Childrens Hosp, Columbus, OH USANehal A. Parikh - Nationwide Childrens Hosp, Columbus, OH USADennis Wallace - RTI (United States)Marie G. Gantz - RTI (United States)Jeanette O'Donnell Auman - RTI (United States)Margaret M. Crawford - RTI (United States)Jenna Gabrio - RTI (United States)Carolyn M. Petrie Huitema - RTI (United States)Kristin M. Zaterka-Baxter - RTI (United States)Krisa P. Van Meurs - Stanford UniversityMarian M. Adams - Stanford UniversityDavid K. Stevenson - Stanford UniversityM. Bethany Ball - Stanford UniversityAndrew W. Palmquist - Stanford UniversityMelinda S. Proud - Stanford UniversityIvan D. Frantz - Tufts Medical CenterJohn M. Fiascone - Tufts Medical CenterBrenda L. MacKinnon - Tufts Medical CenterEllen Nylen - Tufts Medical CenterWaldemar A. Carlo - University of AlabamaNamasivayam Ambalavanan - University of AlabamaMonica Collins - University of AlabamaShirley S. Cosby - University of AlabamaUday Devaskar - Mattel Children's HospitalMeena Garg - Mattel Children's HospitalTeresa Chanlaw - Mattel Children's HospitalRachel Geller - Mattel Children's HospitalEdward F. Bell - University of IowaDan L. Ellsbury - University of IowaJohn A. Widness - University of IowaTarah T. Colaizy - University of IowaKaren J. Johnson - University of IowaDonia B. Campbell - University of IowaJacky R. Walker - University of IowaKristi L. Watterberg - University of New MexicoRobin K. Ohls - University of New MexicoConra Backstrom Lacy - University of New MexicoRebecca A. Tomson - Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USACarol Hartenberger - University of New MexicoSandra Sundquist Beauman - University of New MexicoBarbara Schmidt - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAHaresh Kirpalani - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USASara B. DeMauro - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAKevin C. Dysart - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAAasma S. Chaudhary - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USASoraya Abbasi - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAToni Mancini - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USADara M. Cucinotta - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USAErik A. Jensen - Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USACarl T. D'Angio - University of RochesterRonnie Guillet - University of RochesterSatyan Lakshminrusimha - University of RochesterAnne Marie Reynolds - University of RochesterLinda J. Reubens - University of RochesterRosemary Jensen - University of RochesterDeana Maffett - University of RochesterHolly I. M. Wadkins - University of RochesterMichael G. Sacilowski - University of RochesterAshley Williams - University of RochesterStephanie Guilford - University of RochesterMary Rowan - University of RochesterDiane M. Prinzing - University of RochesterJulianne Hunn - University of RochesterAnn Marie Scorsone - University of RochesterKaren Wynn - University of RochesterMelissa Bowman - University of RochesterDale L. Phelps - University of RochesterAimee Horan - University of RochesterMyra H. Wyckoff - The University of Texas Southwestern Medical CenterLuc P. Brion - The University of Texas Southwestern Medical CenterLijun Chen - The University of Texas Southwestern Medical CenterAlicia Guzman - The University of Texas Southwestern Medical CenterJanet S. Morgan - The University of Texas Southwestern Medical CenterLara Pavageau - The University of Texas Southwestern Medical CenterDiana M. Vasil - The University of Texas Southwestern Medical CenterLizette E. Torres - The University of Texas Southwestern Medical CenterRoger G. Faix - University of UtahBradley A. Yoder - University of UtahKaren A. Osborne - University of UtahKarie Bird - University of UtahJill Burnett - University of UtahJennifer J. Jensen - University of UtahCynthia Spencer - University of UtahKimberlee Weaver-Lewis - University of UtahKaren Zanetti - University of UtahSeetha Shankaran - Wayne State UniversityJohn Barks - Wayne State UniversityRebecca Bara - Wayne State UniversityMary Johnson - Wayne State UniversityMary Christensen - Wayne State UniversityStephanie Wiggins - Wayne State UniversityRichard A. Ehrenkranz - Yale UniversityHarris Jacobs - Yale UniversityPatricia Cervone - Yale UniversityMonica Konstantino - Yale UniversityJoAnn Poulsen - Yale UniversityJanet Taft - Yale UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.85(7), pp.994-1000
- DOI
- 10.1038/s41390-019-0300-4
- PMID
- 30737489
- PMCID
- PMC6531328
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- University of Rochester Medical Center, Golisano Children's Hospital U10 HD53089; UL1 TR41 / University of New Mexico Health Sciences Center MSN RNC-NIC UL1TR001111 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) U10 HD27856; M01 RR750; UL1 TR6 / Wishard Health Services University of Texas Southwestern Medical Center at Dallas University of Pennsylvania, Hospital of the University of Pennsylvania, Pennsylvania Hospital U10 HD34216; M01 RR32; RN BSN MaEd / University of Alabama at Birmingham Health System and Children's Hospital of Alabama BSN RNC-NIC U10 HD21373; RN BSN / McGovern Medical School at The University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital U10 HD68263; M01 RR44; UL1 TR42 / University of Buffalo Women's and Children's Hospital of Buffalo Emory University, Children's Healthcare of Atlanta, Grady Memorial Hospital RN BSN CCRC; U10 HD53124; M01 RR64; UL1 TR105 / University of Utah University Hospital, Intermountain Medical Center, LDS Hospital, and Primary Children's Medical Center UG1HD040689 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10 HD27880; M01 RR70; UL1 TR93 / El Camino Hospital, and Lucile Packard Children's Hospital U10 HD53119; M01 RR54 / Tufts Medical Center, Floating Hospital for Children U10 HD68270 / University of California-Los Angeles, Mattel Children's Hospital, Santa Monica Hospital, Los Robles Hospital and Medical Center, and Olive View Medical Center U10 HD27851; UL1 TR454; RN BS CCRC / Emory University Hospital Midtown U01HL112776 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U10 HD27853; M01 RR8084 / Cincinnati Children's Hospital Medical Center, University Hospital, and Good Samaritan Hospital U10 HD68284; RN BSN CCRC / Children's Mercy Hospital, University of Missouri Kansas City School of Medicine Indiana University, University Hospital, Methodist Hospital, Riley Hospital for Children Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U10 HD21364; M01 RR80 / Case Western Reserve University, Rainbow Babies & Children's Hospital Duke University School of Medicine, University Hospital, University of North Carolina U10 HD40689; M01 RR633 / Children's Medical Center Dallas U10 HD27871; UL1 TR142 / Bridgeport Hospital Eunice Kennedy Shriver National Institute of Child Health and Human Development-Stephanie Wilson Archer, MA Nationwide Children's Hospital; Ohio State University U10 HD36790; RN BSN CCRP / RTI International RN BSN; U10 HD53109; (M01 RR59) / University of Iowa and Mercy Medical Center Wayne State University, University of Michigan U10 HD68278 / Ohio State University Medical Center U10 HD27904 / Alpert Medical School of Brown University U10 HD40492; M01 RR30; UL1 TR83 / Duke Regional Hospital RN BSN; U10 HD21385 / Children's Hospital of Michigan U10 HD68244 / Children's Hospital of Philadelphia
- Language
- English
- Date published
- 06/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354516602771
Metrics
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