Journal article
Promoting activity of the herbicide dicamba (2-methoxy-3, 6-dichlorobenzoic acid) in two stage hepatocarcinogenesis
International journal of oncology, Vol.14(1), pp.79-84
01/1999
DOI: 10.3892/ijo.14.1.79
PMID: 9863012
Abstract
Our goal was to examine whether dicamba, a widely-used broad leaf herbicide, has promoting activity in two-stage hepatocarcinogenesis. Female Sprague Dawley rats were given a single dose of diethylnitrosamine and then diets containing dicamba, or phenobarbital, or both for six months. The number and volume of placental glutathione-S-transferase-positive, glucose-6-phosphatase-negative or ATPase-negative foci were quantified in the liver. Dicamba alone did not increase the number or volume of these altered hepatic foci. Dicamba did, however, show a significant effect on the number or volume of certain markers in animals also treated with phenobarbital. These data show that dicamba in combination with other promoters may have weak promoting activity in two-stage hepatocarcinogenesis in the rat.
Details
- Title: Subtitle
- Promoting activity of the herbicide dicamba (2-methoxy-3, 6-dichlorobenzoic acid) in two stage hepatocarcinogenesis
- Creators
- P Espandiari - Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0305, USAH P GlauertE Y LeeL W Robertson
- Resource Type
- Journal article
- Publication Details
- International journal of oncology, Vol.14(1), pp.79-84
- Publisher
- Greece
- DOI
- 10.3892/ijo.14.1.79
- PMID
- 9863012
- ISSN
- 1019-6439
- eISSN
- 1791-2423
- Grant note
- CA43719 / NCI NIH HHS CA01688 / NCI NIH HHS U07/CCU408035 / PHS HHS
- Language
- English
- Date published
- 01/1999
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002324402771
Metrics
13 Record Views