Journal article
Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
Results and problems in cell differentiation, Vol.59, pp.125-173
2017
DOI: 10.1007/978-3-319-44820-6_5
PMID: 28247048
Abstract
Formation of an oocyte involves a specialized cell division termed meiosis. In meiotic prophase I (the initial stage of meiosis), chromosomes undergo elaborate events to ensure the proper segregation of their chromosomes into gametes. These events include processes leading to the formation of a crossover that, along with sister chromatid cohesion, forms the physical link between homologous chromosomes. Crossovers are formed as an outcome of recombination. This process initiates with programmed double-strand breaks that are repaired through the use of homologous chromosomes as a repair template. The accurate repair to form crossovers takes place in the context of the synaptonemal complex, a protein complex that links homologous chromosomes in meiotic prophase I. To allow proper execution of meiotic prophase I events, signaling processes connect different steps in recombination and synapsis. The events occurring in meiotic prophase I are a prerequisite for proper chromosome segregation in the meiotic divisions. When these processes go awry, chromosomes missegregate. These meiotic errors are thought to increase with aging and may contribute to the increase in aneuploidy observed in advanced maternal age female oocytes.
Details
- Title: Subtitle
- Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
- Creators
- Rachel Reichman - Department of Biology, University of Iowa, Iowa City, IA, 52242, USABenjamin Alleva - Department of Biology, University of Iowa, Iowa City, IA, 52242, USASarit Smolikove - Department of Biology, University of Iowa, Iowa City, IA, 52242, USA. sarit-smolikove@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Results and problems in cell differentiation, Vol.59, pp.125-173
- Publisher
- Germany
- DOI
- 10.1007/978-3-319-44820-6_5
- PMID
- 28247048
- ISSN
- 0080-1844
- eISSN
- 1861-0412
- Language
- English
- Date published
- 2017
- Academic Unit
- Psychiatry; Biology
- Record Identifier
- 9983992044002771
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