Journal article
Prophylactic Indomethacin Revisited
The Journal of pediatrics, Vol.186, pp.11-14.e1
07/2017
DOI: 10.1016/j.jpeds.2017.03.036
PMCID: PMC5520627
PMID: 28396028
Abstract
Persistent patency of the ductus arteriosus (PDA) has challenged
neonatologists for more than 40 years.
1
,
2
Surgical
ligation of the ductus was first performed in children nearly 80 years
ago
3
and proved that
prevention of prolonged exposure to left-to-right shunting through the ductus
arteriosus improved pulmonary, cardiac, and systemic outcomes. In the 1970s, the
discovery that nonsteroidal anti-inflammatory drugs could induce PDA
closure
4
–
7
and are effective in infants
born preterm
8
,
9
provided neonatologists with a pharmacologic
alternative to surgery. The clear advantages, however, of having a medical
approach have been clouded by conflicting information on the long-term benefits
of treatment, disagreement regarding the clinical indicators that warrant
treatment for PDA, optimal drug choice, preferred dosing regimens, and
indecision regarding the best time to treat a select population of fragile
preterm infants.
Details
- Title: Subtitle
- Prophylactic Indomethacin Revisited
- Creators
- Jeff Reese - Department of Pediatrics, Department of Cell and Developmental BiologyElaine L Shelton - Department of Pediatrics, Department of Pharmacology, Vanderbilt University School of Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TennesseeJames C Slaughter - Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TennesseePatrick J McNamara - Department of Neonatology, Department of Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Canada
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.186, pp.11-14.e1
- DOI
- 10.1016/j.jpeds.2017.03.036
- PMID
- 28396028
- PMCID
- PMC5520627
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093461402771
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