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Prophylactic Intrathecal Morphine and Prevention of Post-Dural Puncture Headache A Randomized Double-blind Trial
Journal article   Open access   Peer reviewed

Prophylactic Intrathecal Morphine and Prevention of Post-Dural Puncture Headache A Randomized Double-blind Trial

Feyce M. Peralta, Cynthia A. Wong, Nicole Higgins, Paloma Toledo, Mary Jane Jones and Robert J. McCarthy
Anesthesiology (Philadelphia), Vol.132(5), pp.1045-1052
05/01/2020
DOI: 10.1097/ALN.0000000000003206
PMID: 32108686
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https://doi.org/10.1097/ALN.0000000000003206View
Published (Version of record) Open Access

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Abstract

Background: Prophylactic epidural morphine administration after unintentional dural puncture with a large-bore needle has been shown to decrease the incidence of post-dural puncture headache. The authors hypothesized that prophylactic administration of intrathecal morphine would decrease the incidence of post-dural puncture headache and/or need for epidural blood patch after unintentional dural puncture. Methods: Parturients with an intrathecal catheter in situ after unintentional dural puncture with a 17-g Tuohy needle during intended epidural catheter placement for labor analgesia were enrolled in this randomized, double-blind trial. After delivery, subjects were randomized to receive intrathecal morphine 150 mu g or normal saline. The primary outcome was the incidence of post-dural puncture headache. Secondary outcomes included onset, duration, and severity of post-dural puncture headache, the presence of cranial nerve symptoms and the type of treatment the patient received. Results: Sixty-one women were included in the study. The incidence of post-dural puncture headache was 21 of 27 (78%) in the intrathecal morphine group and 27 of 34 (79%) in the intrathecal saline group (difference, -1%; 95% CI, -25% to 24%). There were no differences between groups in the onset, duration, or severity of headache, or presence of cranial nerve symptoms. Epidural blood patch was administered to 10 of 27 (37%) of subjects in the intrathecal morphine and 11 of 21 (52%) of the intrathecal saline group (difference 15%; 95% CI, -18% to 48%). Conclusions: The present findings suggest that a single prophylactic intrathecal morphine dose of 150 mu g administered shortly after delivery does not decrease the incidence or severity of post-dural puncture headache after unintentional dural puncture. This study does not support the clinical usefulness of prophylactic intrathecal morphine after an unintentional dural puncture.
 Anesthesiology Life Sciences & Biomedicine Science & Technology

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