Journal article
Prophylactic donor lymphocyte infusion for relapse prevention: a meta-analysis
Japanese journal of clinical oncology, Vol.50(6), pp.661-670
06/10/2020
DOI: 10.1093/jjco/hyaa022
PMID: 32100001
Abstract
Objective: Primary disease relapse (PDR) of malignant hematologic conditions after standard hematopoietic stem cell transplant (HSCT) is one of the most challenging diseases; therefore ongoing researches are aiming at relapse prevention and minimizing the transplant-related side effects. Prophylactic donor lymphocytes (pDLI) had been proposed as a valuable strategy for PDR prevention, but early studies had been discouraging due to the limited benefit and possible association with acute graft-versus-host disease (aGVHD). Therefore, we conducted a metaanalysis to evaluate the association between pDLI use, PDR, aGVHD and OS.
Method: We performed a comprehensive literature search in MEDLINE, Cochrane library and Embase database from inception to May 2019 for studies that evaluated the association between pDLI and PDR. We conducted a random effect meta-analysis of 9 studies involving a total of 748 participants (pDLI = 398, non-pDLI = 350) and reported the pooled odd ratio (OR) for association of pDLI use, PDR, aGVHD and OS.
Result: We found a significant decreased odd of PDR in the pDLI group (pooled OR = 0.42, 95% CI 0.30-0.58, I-2 = 0%), but there was no significant increased odd of aGVHD (pooled OR of 0.98, 95% CI 0.56-1.72, I-2 = 0.8%). We also found that there was an increased odd of overall survival (OS) (pooled OR 3.17, 95% CI 1.85-5.45, I-2 = 50.2%).
Conclusion: There are significantly decreased odd of PDR and increased odd of OS in the pDLI group compared to the control group, but there is no statistically significant increased odd of aGVHD as suggested by previous studies. We concluded that pDLI is a potentially valuable method for post-transplant PDR prevention.
Details
- Title: Subtitle
- Prophylactic donor lymphocyte infusion for relapse prevention: a meta-analysis
- Creators
- Kittika Poonsombudlert - University of Hawaii SystemJakrin Kewcharoen - University of Hawaii SystemChattip Prueksapraopong - Navamindradhiraj UniversityNath Limpruttidham - University of Hawaii System
- Resource Type
- Journal article
- Publication Details
- Japanese journal of clinical oncology, Vol.50(6), pp.661-670
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/jjco/hyaa022
- PMID
- 32100001
- ISSN
- 0368-2811
- eISSN
- 1465-3621
- Number of pages
- 10
- Language
- English
- Date published
- 06/10/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984694744802771
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