Journal article
Proprioceptor Pathway Development Is Dependent on MATH1
Neuron (Cambridge, Mass.), Vol.30(2), pp.411-422
05/2001
DOI: 10.1016/S0896-6273(01)00305-1
PMID: 11395003
Abstract
The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway.
Details
- Title: Subtitle
- Proprioceptor Pathway Development Is Dependent on MATH1
- Creators
- Nessan A Bermingham - Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030 USABassem A Hassan - Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030 USAVincent Y Wang - Program in Developmental Biology, One Baylor Plaza, Houston, TX 77030 USAMichael Fernandez - Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030 USASandro Banfi - Telethon Institute of Genetics and Medicine, Via Olgettina 58, 20132 Milan, ItalyHugo J Bellen - Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030 USABernd Fritzsch - Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68178 USAHuda Y Zoghbi - Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030 USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.30(2), pp.411-422
- DOI
- 10.1016/S0896-6273(01)00305-1
- PMID
- 11395003
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 05/2001
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070888902771
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