Prospective Analysis of the Impact of 68Ga-DOTATOC Positron Emission Tomography-Computerized Axial Tomography on Management of Pancreatic and Small Bowel Neuroendocrine Tumors

Silvia N Ghobrial; Yusuf Menda; Gideon K Zamba; Sarah L Mott; Kristin Gaimari-Varner; David Dick; Joseph Dillon; James R Howe; Michael Graham; John Sunderland; Andrew Bellizzi; Thomas M O'Dorisio; M Sue O'Dorisio

doi:10.1097/MPA.0000000000001625

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Prospective Analysis of the Impact of 68Ga-DOTATOC Positron Emission Tomography-Computerized Axial Tomography on Management of Pancreatic and Small Bowel Neuroendocrine Tumors

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Prospective Analysis of the Impact of 68Ga-DOTATOC Positron Emission Tomography-Computerized Axial Tomography on Management of Pancreatic and Small Bowel Neuroendocrine Tumors

Silvia N Ghobrial, Yusuf Menda, Gideon K Zamba, Sarah L Mott, Kristin Gaimari-Varner, David Dick, Joseph Dillon, James R Howe, Michael Graham, John Sunderland, …

Pancreas, Vol.49(8), pp.1033-1036

09/2020

DOI: 10.1097/MPA.0000000000001625

PMCID: PMC7447173

PMID: 32769854

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Abstract

A prospective clinical trial evaluated the effect of Ga-DOTATOC positron emission tomography-computerized axial tomography (PET-CT) on change in management of patients with lung, pancreatic, and small bowel neuroendocrine tumors. The primary eligibility criterion was a histologically proven tumor with positive somatostatin receptor subtype 2A immunohistochemistry. The primary and secondary end points were change in patient management and safety. Referring physicians completed questionnaires pre- and post-Ga-DOTATOC PET-CT, stating current and planned patient management, respectively, with tumor board adjudication of final management decisions. Change in management was categorized as follows: no change; minor change (additional imaging, supportive care); or major change (octreotide/lanreotide therapy, tumor biopsy, surgery, peptide receptor radiotherapy, chemotherapy, biological therapy, liver embolization). A major change in management was recommended for 54 (47.37%) of 114 subjects and a minor change for 6 (5.26%) of 114 subjects, with no change for 54 (47.37%) of 114 subjects. Grade 1 adverse events were observed in 26 of 114 subjects (nausea, headache, back pain, diarrhea); one grade 2 (petechiae) and one grade 3 (abdominal pain) adverse event were observed. No grade 2 or 3 adverse events were related to study drug and none required intervention. Imaging with Ga-DOTATOC PET-CT has a significant impact on management of patients with neuroendocrine tumors.

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Title: Subtitle: Prospective Analysis of the Impact of 68Ga-DOTATOC Positron Emission Tomography-Computerized Axial Tomography on Management of Pancreatic and Small Bowel Neuroendocrine Tumors
Creators: Silvia N Ghobrial - From the Departments of Pediatrics.
Yusuf Menda - Radiology
Gideon K Zamba - Biostatistics
Sarah L Mott - Biostatistics
Kristin Gaimari-Varner - Holden Comprehensive Cancer Center
David Dick - Radiology
Joseph Dillon - Departments of Medicine.
James R Howe - Surgery
Michael Graham - Radiology
John Sunderland - Radiology
Andrew Bellizzi - University of Iowa
Thomas M O'Dorisio - Departments of Medicine
M Sue O'Dorisio - From the Departments of Pediatrics
Resource Type: Journal article
Publication Details: Pancreas, Vol.49(8), pp.1033-1036
DOI: 10.1097/MPA.0000000000001625
PMID: 32769854
PMCID: PMC7447173
NLM abbreviation: Pancreas
ISSN: 0885-3177
eISSN: 1536-4828
Grant note: R01 CA167632 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA174521 / NCI NIH HHS
Language: English
Date published: 09/2020
Academic Unit: Radiology; Stead Family Department of Pediatrics; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Surgery; Physics and Astronomy; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984185279502771

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