Journal article
Prospective analysis of association between statins and pancreatic cancer risk in the Women's Health Initiative
Cancer causes & control, Vol.27(3), pp.415-423
03/2016
DOI: 10.1007/s10552-016-0717-6
PMCID: PMC6849382
PMID: 26857832
Abstract
To determine whether HMG-CoA reductase inhibitors (statins) are associated with a lower risk of pancreatic cancer.
The population included 160,578 postmenopausal women enrolled in the Women's Health Initiative (WHI) in which 385 incident cases of pancreatic cancer were identified over an average of 8.69 (SD ±4.59) years. All diagnoses were confirmed by medical record and pathology review. Information on statin use and other risk factors was collected at baseline and during follow-up. Multivariable-adjusted hazards ratios (HRs) and 95 % confidence intervals (CIs) evaluating the relationship between prior statin use (at baseline only as well as in a time-dependent manner) and risk of pancreatic cancer were computed from Cox proportional hazards regression analyses after adjusting for appropriate confounders. We also evaluated the effect of statin type, potency, lipophilic status, and duration of use. All statistical tests were two-sided.
Statins were used at baseline by 12,243 (7.5 %) women. The annualized rate of pancreatic cancer in statin users and nonusers, respectively, was 0.0298 versus 0.0271 %. The multivariable-adjusted HR for statin users versus nonusers at baseline was 0.92 and 95 % CI 0.57-1.48. In a time-dependent model, the HR for low-potency statins was 0.46, 95 % CI 0.20-1.04. There was no significant effect seen by statin lipophilicity or duration of use.
There was no significant relationship between statins and pancreatic cancer risk in the WHI; however, there was a marginal inverse association noted for low-potency statins. Analyses of larger numbers of cases are needed to further explore this relationship.
Details
- Title: Subtitle
- Prospective analysis of association between statins and pancreatic cancer risk in the Women's Health Initiative
- Creators
- Michael S Simon - Wayne State UniversityPinkal Desai - Cornell UniversityRobert Wallace - University of IowaChunyuan Wu - Fred Hutch Cancer CenterBarbara V Howard - Georgetown-Howard Universities Center for Clinical and Translational ScienceLisa W Martin - George Washington UniversityNicolas Schlecht - Albert Einstein College of MedicineSimin Liu - University of California, Los AngelesAllison JayErin S LeBlanc - Kaiser PermanenteThomas Rohan - Albert Einstein College of MedicineJoAnn Manson - Harvard University
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.27(3), pp.415-423
- DOI
- 10.1007/s10552-016-0717-6
- PMID
- 26857832
- PMCID
- PMC6849382
- NLM abbreviation
- Cancer Causes Control
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Grant note
- P30CA022453 / NCI NIH HHS
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363642702771
Metrics
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