Journal article
Prospective assessment of pituitary size and shape on MR imaging after suppressive hormonal therapy in central precocious puberty
Pediatric radiology, Vol.30(7), pp.444-446
2000
DOI: 10.1007/s002470000223
PMID: 10929361
Abstract
Objective: The diagnostic significance of an enlarged pituitary gland regarding both shape and size parameters on MR imaging has previously been demonstrated in children with central precocious puberty. This study was designed to assess changes in these parameters following successful suppressive therapy of central precocious puberty with the gonadotropin-releasing hormone (GnRH) analogue.
Materials and methods: Twelve girls (mean age 7.3 years) with central precocious puberty were prospectively enrolled in our study protocol. Sagittal and coronal MR images of the pituitary region were obtained in all patients before treatment and after at least 6 months of GnRH analogue therapy (mean 18.0 months). Parameters measured included pituitary gland height, length, width, sagittal cross-sectional area, and volume.
Results: All patients had excellent clinical response to treatment with arrest of secondary sexual development, normalization of serum estradiol levels, and complete obliteration of the LH response to diagnostic GnRH stimulation. No significant change occurred in any pituitary size or shape parameter following GnRH analogue therapy.
Conclusion: Favorable clinical response to GnRH analogue therapy in central precocious puberty is not accompanied by significant a change in pituitary gland size and shape.
Details
- Title: Subtitle
- Prospective assessment of pituitary size and shape on MR imaging after suppressive hormonal therapy in central precocious puberty
- Creators
- J. T VAN BEEK - Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, United StatesM. J. A SHARAFUDDIN - Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, United StatesS. C. S KAO - Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, United StatesA LUISIRI - Cardinal Glennon Children's Hospital, St. Louis, Missouri, United StatesL. R GARIBALDI - Children's Hospital of New Jersey, Newark Beth Israel Medical Center, Newark, New Jersey, United States
- Resource Type
- Journal article
- Publication Details
- Pediatric radiology, Vol.30(7), pp.444-446
- Publisher
- Springer; Berlin
- DOI
- 10.1007/s002470000223
- PMID
- 10929361
- ISSN
- 0301-0449
- eISSN
- 1432-1998
- Language
- English
- Date published
- 2000
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984051796002771
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