Journal article
Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI)
The American journal of clinical nutrition, Vol.94(6), pp.1471-1478
12/2011
DOI: 10.3945/ajcn.111.017715
PMCID: PMC3252547
PMID: 22030222
Abstract
Prospective epidemiologic data on the association between vitamin D and all-cause and cause-specific mortality are limited.
This study aimed to determine whether 25-hydroxyvitamin D [25(OH)D] concentrations were prospectively and independently associated with cardiovascular disease (CVD), cancer, and all-cause mortality in postmenopausal women.
A substudy in 2429 postmenopausal women within the Women's Health Initiative (WHI) with measured baseline 25(OH)D concentrations were followed for 10 y for death from CVD, cancer, and all-cause mortality. Proportional hazards models were performed to evaluate quartiles of month-adjusted 25(OH)D concentrations, with adjustment for potential confounders. Sequential model building and analysis for multiplicative interaction were performed to evaluate the effects of central adiposity on the association of low 25(OH)D with all-cause mortality.
Of the 2429 women, 224 deaths occurred, with 79 deaths from CVD and 62 deaths from cancer. Multivariate-adjusted HRs that compared quartiles 1 (lowest) to 4 (highest) of 25(OH)D for all-cause mortality (HR: 1.25; 95% CI: 0.80, 1.95), CVD mortality (HR: 1.27; 95% CI: 0.81, 1.99), and cancer mortality (HR: 1.39; 95% CI: 0.88, 2.19) were not significant. There was a potential interaction (P = 0.08) between abdominal obesity and low 25(OH)D concentrations that showed an increased risk of the lowest quartile of 25(OH)D concentrations (HR: 1.85; 95% CI: 1.00, 3.44) with increased mortality in women with a normal waist circumference but no increased risk in women with abdominal obesity (HR: 0.96; 95% CI: 0.52, 1.76).
Body fat distribution may play an important role in the modulation of the effect of low vitamin D concentrations on health. This trial was registered at clinicaltrials.gov as NCT 00000611.
Details
- Title: Subtitle
- Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI)
- Creators
- Charles B Eaton - Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA. charles_eaton@mhri.orgAlicia YoungMatthew A AllisonJennifer RobinsonLisa W MartinLewis H KullerKaren C JohnsonJ David CurbLinda Van HornAnne McTiernanSimin LiuJoAnn E Manson
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.94(6), pp.1471-1478
- Publisher
- United States
- DOI
- 10.3945/ajcn.111.017715
- PMID
- 22030222
- PMCID
- PMC3252547
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Grant note
- N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH32100-2 / WHI NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32118-32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS N01WH32105-6 / WHI NIH HHS N01WH24152 / WHI NIH HHS
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995034902771
Metrics
15 Record Views