Prospective polysomnographic analysis of obstructive sleep apnea in down syndrome

Mark Eric Dyken; Deborah C Lin-Dyken; Susan Poulton; M Bridget Zimmerman; Erin Sedars

doi:10.1001/archpedi.157.7.655

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Prospective polysomnographic analysis of obstructive sleep apnea in down syndrome

Journal article

Open access

Peer reviewed

Prospective polysomnographic analysis of obstructive sleep apnea in down syndrome

Mark Eric Dyken, Deborah C Lin-Dyken, Susan Poulton, M Bridget Zimmerman and Erin Sedars

Archives of pediatrics & adolescent medicine, Vol.157(7), pp.655-660

07/2003

DOI: 10.1001/archpedi.157.7.655

PMID: 12860786

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Abstract

To investigate obstructive sleep apnea (OSA) in a consecutively encountered, nonselected population of young patients with Down syndrome using standard overnight polysomnography and to determine the effects of therapy. In a population of patients seen for routine developmental evaluations, 9 boys and 10 girls were studied using standard overnight polysomnography. Using pediatric standards, OSA was found in 79% of the subjects (95% confidence interval, 54%-94%), with a median apnea index of 3 events per hour (interquartile range, 2-5), a median apnea-hypopnea index of 6 events per hour (interquartile range, 3-8), and a median arterial oxygen saturation (SaO2) low point of 88% (interquartile range, 84%-90%). Higher body mass index was significantly associated with a higher apnea index and a lower SaO2 level, and there was a significant inverse relationship between age and the lowest SaO2 value as well as a possible association between sleep-related symptoms at the time of diagnosis and the lowest SaO2 value. In addition, patients with OSA had a significantly higher movement arousal index than those without OSA. Using rigid polysomnographic standards, this pilot study revealed OSA in a high percentage of young subjects with Down syndrome and an association between OSA and obesity, age, and poor sleep quality. These findings justify larger and more detailed population studies to further define clinical factors that are concomitant with OSA in Down syndrome and to improve therapy.

Body Mass Index

Sleep Apnea, Obstructive - therapy

Prospective Studies

Age Factors

Obesity - complications

Humans

Child, Preschool

Male

Treatment Outcome

Polysomnography

Positive-Pressure Respiration

Oxygen - blood

Adenoidectomy

Sleep Apnea, Obstructive - etiology

Pilot Projects

Posture - physiology

Tonsillectomy

Adolescent

Down Syndrome - complications

Female

Child

Sleep Apnea, Obstructive - diagnosis

Details

Title: Subtitle: Prospective polysomnographic analysis of obstructive sleep apnea in down syndrome
Creators: Mark Eric Dyken - Roy J. and Lucille A. Carver College of Medicine, Department of Neurology Sleep Disorders Center, University of Iowa, Iowa City 52242, USA. mark-dyken@uiowa.edu
Deborah C Lin-Dyken
Susan Poulton
M Bridget Zimmerman
Erin Sedars
Resource Type: Journal article
Publication Details: Archives of pediatrics & adolescent medicine, Vol.157(7), pp.655-660
DOI: 10.1001/archpedi.157.7.655
PMID: 12860786
NLM abbreviation: Arch Pediatr Adolesc Med
ISSN: 1072-4710
eISSN: 1538-3628
Publisher: American Medical Association; United States
Language: English
Date published: 07/2003
Academic Unit: Neurology; Stead Family Department of Pediatrics; Biostatistics; Developmental and Behavioral Pediatrics
Record Identifier: 9983997325602771

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