Journal article
Prospective study of muscle cramps in Charcot‐Marie‐Tooth disease
Muscle & nerve, Vol.51(4), pp.485-488
04/2015
DOI: 10.1002/mus.24333
PMCID: PMC4860275
PMID: 25042364
Abstract
ABSTRACT
Introduction: This study aims to assess the frequency, location, severity, duration, and fluctuation over time of muscle cramps in Charcot‐Marie‐Tooth disease (CMT). Methods: Inherited Neuropathies Consortium Contact Registry participants recorded the occurrence and characteristics of muscle cramps using an 11‐question survey administered 3 times over 8 weeks. Results: A total of 110 adult patients with CMT completed the survey. Weekly cramp frequency was 9.3 (SD 12.3), and 23% had daily muscle cramps. Twenty‐two percent reported a significant impact on quality of life. Over 8 weeks, the daily frequency and severity of muscle cramps did not change significantly. Conclusions: Patients with CMT have muscle cramps that vary little over an 8‐week period, and they may interfere with quality of life. These data may be useful in the planning of clinical trials of agents to treat adults with CMT‐associated muscle cramps. Muscle Nerve 51: 485–488, 2015
Details
- Title: Subtitle
- Prospective study of muscle cramps in Charcot‐Marie‐Tooth disease
- Creators
- Nicholas E Johnson - The University of Rochester Medical CenterJanet Sowden - The University of Rochester Medical CenterNuran Dilek - The University of Rochester Medical CenterKaty Eichinger - The University of Rochester Medical CenterJoshua Burns - The University of Sydney & The Children's Hospital at WestmeadMichael P Mcdermott - The University of Rochester Medical CenterMichael E Shy - The University of IowaDavid N Herrmann - The University of Rochester Medical Center
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.51(4), pp.485-488
- DOI
- 10.1002/mus.24333
- PMID
- 25042364
- PMCID
- PMC4860275
- NLM abbreviation
- Muscle Nerve
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Number of pages
- 4
- Grant note
- National Center for Research Resources (NEJ) (8UL1TR000105 (formerly UL1RR025764)) Inherited Neuropathy Consortium RDCRN NINDS (1U54NS0657) The Office of Rare Diseases, and the Muscular Dystrophy Association
- Language
- English
- Date published
- 04/2015
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020749002771
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