Journal article
Prostaglandins Contribute to Activation of Baroreceptors in Rabbits: Possible Paracrine Influence of Endothelium
Circulation research, Vol.67(6), pp.1394-1404
12/1990
DOI: 10.1161/01.RES.67.6.1394
PMID: 2245501
Abstract
The purpose of this study was to test the hypothesis that prostaglandins released from vascular endothelial cells contribute to activation of baroreceptors during increases in arterial pressure. Baroreceptor activity was recorded from the vascularly isolated carotid sinus in rabbits anesthetized with chloralose. Baroreceptor activity was measured during ramp or step increases in nonpulsatile carotid sinus pressure over a range of 0–175 mm Hg. Exposure of the isolated carotid sinus to inhibitors of prostaglandin formation (indomethacin [n = 10] or aspirin [n=6]) decreased baroreceptor activity significantly (p<0.05). The slope of the pressure-activity relation averaged 0.80±0.07 %/mm Hg (mean±SEM) during control measurements and 0.72±0.06 and 0.63±0.05 %/mm Hg during exposure to 10 and 20 μM indomethacin, respectively. Exposure of the carotid sinus to exogenous prostacyclin (PGI2 [n=11]) increased baroreceptor activity significantly. The slope of the pressure-activity relation averaged 0.89±0.10, 1.09±0.09, and 1.26±0.16 %/mm Hg during control and during exposure to 10 and 20 μM PGI2, respectively. Activity returned to control after removal of PGI2 (0.89±0.12 %/mm Hg). Removal of endothelium with either a balloon catheter (n=4) or a jet of a 95% O2-5% CO2 gas mixture (n=6) decreased the slope of the pressure-activity relation from 0.92±0.09 to 0.56±0.08 %/mm Hg (p<0.05). Exposure of the denuded sinus to exogenous PGI2 (20 μM [n=4]) restored activity (slope=1.09±0.24 %/mmHg). Neither indomethacin (n=5) nor PGI2 (n=5) nor denudation (n=5) significantly altered the pressure-diameter relation of the carotid sinus (sonomicrometers), suggesting that the effects on baroreceptor discharge are not caused by altered stretch of the carotid sinus at a given pressure. The results suggest that prostaglandins (e.g., PGI2) released from endothelium contribute in a paracrine manner to activation of baroreceptors during increases in arterial pressure.
Details
- Title: Subtitle
- Prostaglandins Contribute to Activation of Baroreceptors in Rabbits: Possible Paracrine Influence of Endothelium
- Creators
- Hsing Chen - Cardiovascular Center and the Departments of Internal Medicine and Physiology and Biophysics, The University of Iowa College of Medicine, and the Department of Veterans Affairs Medical Center, Iowa City, Iowa, and the Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaMark ChapleauThomas McDowellFrancois Abboud
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.67(6), pp.1394-1404
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.67.6.1394
- PMID
- 2245501
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 12/1990
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025402902771
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