Journal article
Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis
microPublication biology, Vol.2025
2025
DOI: 10.17912/micropub.biology.001571
PMCID: PMC12006845
PMID: 40255252
Abstract
Expression of GFP-Actin results in nuclear actin rod formation during specific stages of
oogenesis. Loss of prostaglandin (PG) synthesis and signaling results in an increased frequency of cells with nuclear actin rods; there are less rods per cell, but the rods are longer. These findings suggest that loss of PGs results in increased nuclear actin and are consistent with prior findings assessing the roles of PGs in modulating endogenous nuclear actin. Thus, GFP-Actin rod formation can be used as a tool to screen for new regulators of nuclear actin.
Details
- Title: Subtitle
- Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis
- Creators
- Tina L Tootle - University of Iowa
- Resource Type
- Journal article
- Publication Details
- microPublication biology, Vol.2025
- DOI
- 10.17912/micropub.biology.001571
- PMID
- 40255252
- PMCID
- PMC12006845
- NLM abbreviation
- MicroPubl Biol
- ISSN
- 2578-9430
- eISSN
- 2578-9430
- Language
- English
- Date published
- 2025
- Academic Unit
- Anatomy and Cell Biology; Biology
- Record Identifier
- 9984813194702771
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