Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer

Kristin A. Plichta; Stephen A. Graves; John M. Buatti

doi:10.3390/ijms222212095

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Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer

Journal article

Open access

Peer reviewed

Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer

Kristin A. Plichta, Stephen A. Graves and John M. Buatti

International journal of molecular sciences, Vol.22(22), p.12095

11/01/2021

DOI: 10.3390/ijms222212095

PMCID: PMC8621856

PMID: 34829977

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https://doi.org/10.3390/ijms222212095View

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Abstract

Theranostics, a combination of therapy and diagnostics, is a field of personalized medicine involving the use of the same or similar radiopharmaceutical agents for the diagnosis and treatment of patients. Prostate-specific membrane antigen (PSMA) is a promising theranostic target for the treatment of prostate cancers. Diagnostic PSMA radiopharmaceuticals are currently used for staging and diagnosis of prostate cancers, and imaging can predict response to therapeutic PSMA radiopharmaceuticals. While mainly used in the setting of metastatic, castrate-resistant disease, clinical trials are investigating the use of PSMA-based therapy at earlier stages, including in hormone-sensitive or hormone-naive prostate cancers, and in oligometastatic prostate cancers. This review explores the use of PSMA as a theranostic target and investigates the potential use of PSMA in earlier stage disease, including hormone-sensitive metastatic prostate cancer, and oligometastatic prostate cancer.

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Details

Title: Subtitle: Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer
Creators: Kristin A. Plichta - University of Iowa
Stephen A. Graves - University of Iowa
John M. Buatti - University of Iowa
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.22(22), p.12095
DOI: 10.3390/ijms222212095
PMID: 34829977
PMCID: PMC8621856
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: Mdpi
Number of pages: 10
Language: English
Date published: 11/01/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984303902802771

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