Journal article
Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy
World journal of urology, Vol.40(8), pp.2017-2023
08/01/2022
DOI: 10.1007/s00345-022-04065-5
PMID: 35689106
Abstract
Purpose
Radical prostatectomy (RP) outcomes in Hispanic men with prostate cancer are not well-described. Prior studies showed varying results regarding the rate of upgrading and upstaging, and these studies included limited pathologic data and lack of central pathology review. We characterized the rate of upgrading, adverse pathology, and oncologic outcomes in Hispanics after prostatectomy using a large institutional database.
Methods
We included Hispanic white (HW), non-Hispanic white (NHW), and black men who underwent (RP) between 2010 and 2021 at a single institution. We recorded differences in grade group between biopsy and prostatectomy and performed multivariable analyses for odds of upgrading and adverse pathologic findings. The primary outcome was rate of upgrading in HWs. Using a sub-cohort with follow-up data, we assessed race/ethnicity and upgrading as a predictor of biochemical recurrence (BCR)-free survival.
Results
Our cohort included 1877 men: 36.7% were NHW, 40.6% were HW, and 22.7% were black. Rates of upgrading were not different between NHW, NHW, and black men at 34.0, 33.8, and 37.3%, respectively (
p
= 0.4). In the multivariable analysis for upgrading, significant predictors for upgrading were older age (
p
= 0.002), higher PSA (
p
< 0.001), and lower prostate weight (
p
= 0.02), but race/ethnicity did not predict upgrading. In patients with available follow-up (1083, 58%), upgrading predicted worse BCR-free survival (HR 2.17, CI 1.46–3.22,
p
< 0.0001) but race/ethnicity did not.
Conclusions
HW men undergoing RP had similar rates of upgrading and adverse pathologic outcomes as NHW men. Race/ethnicity does not independently predict upgrading or worse oncologic outcomes after RP.
Details
- Title: Subtitle
- Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy
- Creators
- Helen Y. Hougen - University of MiamiOleksii A. Iakymenko - University of MiamiSanoj Punnen - University of MiamiChad R. Ritch - University of MiamiBruno Nahar - University of MiamiDipen J. Parekh - University of MiamiOleksandr N. Kryvenko - University of MiamiMark L. Gonzalgo - University of Miami
- Resource Type
- Journal article
- Publication Details
- World journal of urology, Vol.40(8), pp.2017-2023
- Publisher
- Springer Berlin Heidelberg
- DOI
- 10.1007/s00345-022-04065-5
- PMID
- 35689106
- ISSN
- 0724-4983
- eISSN
- 1433-8726
- Number of pages
- 7
- Language
- English
- Date published
- 08/01/2022
- Academic Unit
- Urology
- Record Identifier
- 9984701652802771
Metrics
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