Journal article
Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA >10 ng/mL: Results from a Multicenter Study in China
The Prostate, Vol.77(11), pp.1221-1229
08/2017
DOI: 10.1002/pros.23382
PMID: 28664580
Abstract
The performance of prostate health index (phi) in predicting prostate biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the performance of phi remains unknown in patients with PSA >10 ng/mL, the vast majority in Chinese biopsy patients. We aimed to assess the ability of phi to predict prostate cancer (PCa) and high-grade disease (Gleason Score ≥7) on biopsy in a Chinese population.
This is a prospective, observational, multi-center study of consecutive patients who underwent a transrectal ultrasound guided prostate biopsy at four hospitals in Shanghai, China from August 2013 to December 2014.
In the cohort of 1538 patients, the detection rate of PCa was 40.2%. phi had a significantly better predictive performance for PCa than total PSA (tPSA). The areas under the receiver operating characteristic curve (AUC) were 0.90 and 0.79 for phi and tPSA, respectively, P < 0.0001. A considerable proportion of patients in the cohort had PSAs >10 ng/mL (N = 838, 54.5%). The detection rates of PCa were 35.9% and 57.7% in patients with tPSA 10.1-20 and 20.1-50 ng/mL, respectively. The AUCs of phi (0.79 and 0.89, for these two groups, respectively) were also significantly higher than tPSA (0.57 and 0.63, respectively), both P < 0.0001. If a phi ≤35 was used as the cutoff, 599/1538 (39%) biopsies could have been avoided at a cost of missing small numbers of PCa patients: 49 (7.93%) PCa patients, including 18 (3.69%) high-grade tumors.
Results from this study suggest that phi can be used to predict PCa and high-grade disease in Chinese men with high PSA levels (>10 ng/mL).
Details
- Title: Subtitle
- Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA >10 ng/mL: Results from a Multicenter Study in China
- Creators
- Rong Na - Huashan HospitalDingwei Ye - Fudan University Shanghai Cancer CenterJun Qi - XinHua HospitalFang Liu - Huashan HospitalBrian T Helfand - NorthShore University HealthSystemCharles B Brendler - NorthShore University HealthSystemCarly A Conran - NorthShore University HealthSystemVignesh Packiam - NorthShore University HealthSystemJian Gong - Huashan HospitalYishuo Wu - Fudan UniversitySiqun L Zheng - NorthShore University HealthSystemZengnan Mo - Guangxi Medical UniversityQiang Ding - Huashan HospitalYinghao Sun - Second Military Medical UniversityJianfeng Xu - Huashan Hospital
- Resource Type
- Journal article
- Publication Details
- The Prostate, Vol.77(11), pp.1221-1229
- DOI
- 10.1002/pros.23382
- PMID
- 28664580
- ISSN
- 0270-4137
- eISSN
- 1097-0045
- Grant note
- DOI: 10.13039/501100008750, name: Shanghai Hospital Development Center, award: SHDC12015105; name: the National Key Basic Research Program Grant 973 of China, award: 2012CB518301; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81130047, 81402339
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Urology
- Record Identifier
- 9984319968402771
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