Journal article
Proteasome expression and activity in cancer and cancer stem cells
Tumor biology, Vol.39(3), pp.1-17
03/01/2017
DOI: 10.1177/1010428317692248
PMID: 28345458
Abstract
Proteasome is a multi-protein organelle that participates in cellular proteostasis by destroying damaged or short-lived proteins in an organized manner guided by the ubiquitination signal. By being in a central place in the cellular protein complement homeostasis, proteasome is involved in virtually all cell processes including decisions on cell survival or death, cell cycle, and differentiation. These processes are important also in cancer, and thus, the proteasome is an important regulator of carcinogenesis. Cancers include a variety of cells which, according to the cancer stem cell theory, descend from a small percentage of cancer stem cells, alternatively termed tumor-initiating cells. These cells constitute the subsets that have the ability to propagate the whole variety of cancer and repopulate tumors after cytostatic therapies. Proteasome plays a role in cellular processes in cancer stem cells, but it has been found to have a decreased function in them compared to the rest of cancer cells. This article will discuss the transcriptional regulation of proteasome sub-unit proteins in cancer and in particular cancer stem cells and the relationship of the proteasome with the pluripotency that is the defining characteristic of stem cells. Therapeutic opportunities that present from the understanding of the proteasome role will also be discussed.
Details
- Title: Subtitle
- Proteasome expression and activity in cancer and cancer stem cells
- Creators
- Ioannis A. Voutsadakis - Sault Area Hosp, Div Med Oncol, Dept Internal Med, 750 Great Northern Rd, Sault Ste Marie, ON P6B 0A8, Canada
- Resource Type
- Journal article
- Publication Details
- Tumor biology, Vol.39(3), pp.1-17
- DOI
- 10.1177/1010428317692248
- PMID
- 28345458
- NLM abbreviation
- Tumour Biol
- ISSN
- 1010-4283
- eISSN
- 1423-0380
- Publisher
- Sage
- Number of pages
- 17
- Language
- English
- Date published
- 03/01/2017
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806507102771
Metrics
4 Record Views