Journal article
Proteasome regulators in pancreatic cancer
World journal of gastrointestinal oncology, Vol.14(1), pp.38-54
01/15/2022
DOI: 10.4251/wjgo.v14.i1.38
PMCID: PMC8790418
PMID: 35116102
Abstract
Pancreatic adenocarcinoma is one of the most lethal cancers with rising incidence. Despite progress in its treatment, with the introduction of more effective chemotherapy regimens in the last decade, prognosis of metastatic disease remains inferior to other cancers with long term survival being the exception. Molecular characterization of pancreatic cancer has elucidated the landscape of the disease and has revealed common lesions that contribute to pancreatic carcinogenesis. Regulation of proteostasis is critical in cancers due to increased protein turnover required to support the intense metabolism of cancer cells. The proteasome is an integral part of this regulation and is regulated, in its turn, by key transcription factors, which induce transcription of proteasome structural units. These include FOXO family transcription factors, NFE2L2, hHSF1 and hHSF2, and NF-Y. Networks that encompass proteasome regulators and transduction pathways dysregulated in pancreatic cancer such as the KRAS/BRAF/MAPK and the Transforming growth factor beta/SMAD pathway contribute to pancreatic cancer progression. This review discusses the proteasome and its transcription factors within the pancreatic cancer cellular micro-environment. We also consider the role of stemness in carcinogenesis and the use of proteasome inhibitors as therapeutic agents.
Details
- Title: Subtitle
- Proteasome regulators in pancreatic cancer
- Creators
- Nirosha J. Murugan - Algoma UniversityIoannis A. Voutsadakis - Sault Area Hosp, Dept Med Oncol, 750 Great Northern Rd, Sault Ste Marie, ON P6A 3T6, Canada
- Resource Type
- Journal article
- Publication Details
- World journal of gastrointestinal oncology, Vol.14(1), pp.38-54
- DOI
- 10.4251/wjgo.v14.i1.38
- PMID
- 35116102
- PMCID
- PMC8790418
- NLM abbreviation
- World J Gastrointest Oncol
- ISSN
- 1948-5204
- eISSN
- 1948-5204
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 17
- Language
- English
- Date published
- 01/15/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806602302771
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