Journal article
Protecting against promiscuity: the regulatory role of insulators
Cellular and molecular life sciences : CMLS, Vol.59(12), pp.2112-2127
12/2002
DOI: 10.1007/s000180200011
PMID: 12568337
Abstract
Eukaryotic genomes contain transcriptional regulatory elements that alter promoter activity through long-range interactions. Many control elements show a broad range of promoter interactions, suggesting that these elements are capable of inappropriate transcription. The identification of a novel class of directing regulatory elements, called insulators, has provided clues into mechanisms used in eukaryotic genomes to maintain transcription fidelity. Insulators contribute to the organization of independent domains of gene function by restricting enhancer and silencer function. This review describes the properties of insulators and related elements that have been isolated from several eukaryotic genomes. Two classes of models of insulator function are considered. These models provide insights into possible mechanisms used by these diverse elements to provide regulatory autonomy.
Details
- Title: Subtitle
- Protecting against promiscuity: the regulatory role of insulators
- Creators
- P K Geyer - Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA. pamela-geyer@uiowa.eduI Clark
- Resource Type
- Journal article
- Publication Details
- Cellular and molecular life sciences : CMLS, Vol.59(12), pp.2112-2127
- DOI
- 10.1007/s000180200011
- PMID
- 12568337
- NLM abbreviation
- Cell Mol Life Sci
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- Publisher
- Switzerland
- Language
- English
- Date published
- 12/2002
- Academic Unit
- Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984025298902771
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