Journal article
Protection of the blood-brain barrier by hypercapnia during acute hypertension
The American journal of physiology, Vol.251(2 Pt 2), pp.H282-H287
08/1986
DOI: 10.1152/ajpheart.1986.251.2.H282
PMID: 3740284
Abstract
The purpose of this study was to examine effects of hypercapnia on susceptibility of the blood-brain barrier to disruption during acute hypertension. Two methods were used to test the hypothesis that cerebral vasodilatation during hypercapnia increases disruption of the blood-brain barrier. First, permeability of the blood-brain barrier was measured in anesthetized cats with 125I-labeled serum albumin. Severe hypertension markedly increased permeability of the blood-brain barrier during normocapnia, but not during hypercapnia. The protective effect of hypercapnia was not dependent on sympathetic nerves. Second, in anesthetized rats, permeability of the barrier was quantitated by clearance of fluorescent dextran. Disruption of the blood-brain barrier during hypertension was decreased by hypercapnia. Because disruption of the blood-brain barrier occurred primarily in pial venules, we also measured pial venular diameter and pressure (with a servo-null method). Acute hypertension increased pial venular pressure and diameter in normocapnic rats. Hypercapnia alone increased pial venular pressure and pial venular diameter, and acute hypertension during hypercapnia further increased venular pressure. The magnitude of increase in pial venular pressure during acute hypertension was significantly less in hypercapnic than in normocapnic rats. We conclude that hypercapnia protects the blood-brain barrier. Possible mechanisms of this effect include attenuation of the incremental increase in pial venular pressure by hypercapnia or a direct effect on the blood-brain barrier not related to venous pressure.
Details
- Title: Subtitle
- Protection of the blood-brain barrier by hypercapnia during acute hypertension
- Creators
- Gary L BaumbachWilliam G MayhanDonald D Heistad
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.251(2 Pt 2), pp.H282-H287
- DOI
- 10.1152/ajpheart.1986.251.2.H282
- PMID
- 3740284
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Publisher
- United States
- Grant note
- HL-16066 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL 22149 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/1986
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040444902771
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