Journal article
Protective Capacity of Memory CD8 + T Cells Is Dictated by Antigen Exposure History and Nature of the Infection
Immunity (Cambridge, Mass.), Vol.34(5), pp.781-793
2011
DOI: 10.1016/j.immuni.2011.03.020
PMCID: PMC3103642
PMID: 21549619
Abstract
Infection or vaccination confers heightened resistance to pathogen rechallenge because of quantitative and qualitative differences between naive and primary memory T cells. Herein, we show that secondary (boosted) memory CD8
+ T cells were better than primary memory CD8
+ T cells in controlling some, but not all acute infections with diverse pathogens. However, secondary memory CD8
+ T cells were less efficient than an equal number of primary memory cells at preventing chronic LCMV infection and are more susceptible to functional exhaustion. Importantly, localization of memory CD8
+ T cells within lymph nodes, which is reduced by antigen restimulation, was critical for both viral control in lymph nodes and for the sustained CD8
+ T cell response required to prevent chronic LCMV infection. Thus, repeated antigen stimulation shapes memory CD8
+ T cell populations to either enhance or decrease per cell protective immunity in a pathogen-specific manner, a concept of importance in vaccine design against specific diseases.
► Secondary (boosted) memory CD8
+ T cells protect better against some acute infections ► Secondary memory CD8
+ T cells are more “exhaustible” than primary memory cells ► Primary memory CD8
+ T cells are better at preventing chronic LCMV infection ► Lymph node entry is critical for memory CD8
+ T cell protection against chronic LCMV
Details
- Title: Subtitle
- Protective Capacity of Memory CD8 + T Cells Is Dictated by Antigen Exposure History and Nature of the Infection
- Creators
- Jeffrey C Nolz - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USAJohn T Harty - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.34(5), pp.781-793
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.immuni.2011.03.020
- PMID
- 21549619
- PMCID
- PMC3103642
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 2011
- Academic Unit
- Pathology
- Record Identifier
- 9984047863602771
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