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Protective Effect of Calcium Channel Blocker Verapamil on Morphological and Functional State of Hair Cells of the Organ of Corti in Experimental Kanamycin-Induced Ototoxicity
Journal article   Peer reviewed

Protective Effect of Calcium Channel Blocker Verapamil on Morphological and Functional State of Hair Cells of the Organ of Corti in Experimental Kanamycin-Induced Ototoxicity

S Zhuravskii, A Lopotko, V Tomson, A Ivanov, A Chomskii and K Nurskii
Bulletin of experimental biology and medicine, Vol.133(4), pp.404-408
04/2002
DOI: 10.1023/A:1016222810509
PMID: 12124659

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Abstract

The protective effect of verapamil against acute ototoxic sensorineural damage produced by intraperitoneal injections of kanamycin (50 mg/kg daily for 14 day) was studied on rats. The functional (otoacoustic emission), histological, and physiological methods proved the protective effect of daily injections of calcium channel blocker verapamil (2 mg/kg) on the state of hair cells of the organ of Corti.
Oncology Pathology Biochemistry, general Biophysics/Biomedical Physics Medicine & Public Health ototoxicity verapamil otoprotection kanamycin Pharmacology/Toxicology cochlear hair cells

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