Journal article
Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations
The Journal of experimental medicine, Vol.188(9), pp.1705-1715
11/02/1998
DOI: 10.1084/jem.188.9.1705
PMCID: PMC2212518
PMID: 9802982
Abstract
A basic principle of immunology is that prior immunity results in complete protection against a homologous agent. In this study, we show that memory T cells specific to unrelated viruses may alter the host's primary immune response to a second virus. Studies with a panel of heterologous viruses, including lymphocytic choriomeningitis (LCMV), Pichinde (PV), vaccinia (VV), and murine cytomegalo (MCMV) viruses showed that prior immunity with one of these viruses in many cases enhanced clearance of a second unrelated virus early in infection. Such protective immunity was common, but it depended on the virus sequence and was not necessarily reciprocal. Cell transfer studies showed that both CD4 and CD8 T cell populations from LCMV-immune mice were required to transfer protective immunity to naive hosts challenged with PV or VV. In the case of LCMV-immune versus naive mice challenged with VV, there was an enhanced early recruitment of memory phenotype interferon (IFN) γ–secreting CD4
+
and CD8
+
cells into the peritoneal cavity and increased IFN-γ levels in this initial site of virus replication. Studies with IFN-γ receptor knockout mice confirmed a role for IFN-γ in mediating the protective effect by LCMV-immune T cell populations when mice were challenged with VV but not PV. In some virus sequences memory cell populations, although clearing the challenge virus more rapidly, elicited enhanced IFN-γ–dependent immunopathogenesis in the form of acute fatty necrosis. These results indicate that how a host responds to an infectious agent is a function of its history of previous infections and their influence on the memory T cell pool.
Details
- Title: Subtitle
- Protective Heterologous Antiviral Immunity and Enhanced Immunopathogenesis Mediated by Memory T Cell Populations
- Creators
- Liisa K Selin - From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655Steven M Varga - From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655Iris C Wong - From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655Raymond M Welsh - From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.188(9), pp.1705-1715
- Publisher
- The Rockefeller University Press
- DOI
- 10.1084/jem.188.9.1705
- PMID
- 9802982
- PMCID
- PMC2212518
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 11/02/1998
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083823502771
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