Protective cranial implant caps for macaques

Brook A L Perry; Stuart Mason; Jennifer Nacef; Ashley Waddle; Brian Hynes; Caroline Bergmann; Michael C Schmid; Christopher I Petkov; Alexander Thiele; Anna S Mitchell

doi:10.1016/j.jneumeth.2020.108992

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Protective cranial implant caps for macaques

Journal article

Open access

Peer reviewed

Protective cranial implant caps for macaques

Brook A L Perry, Stuart Mason, Jennifer Nacef, Ashley Waddle, Brian Hynes, Caroline Bergmann, Michael C Schmid, Christopher I Petkov, Alexander Thiele and Anna S Mitchell

Journal of neuroscience methods, Vol.348, pp.108992-108992

01/15/2021

DOI: 10.1016/j.jneumeth.2020.108992

PMCID: PMC7840592

PMID: 33130051

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https://doi.org/10.1016/j.jneumeth.2020.108992View

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Abstract

Neuroscience studies with macaque monkeys may require cranial implants to stabilize the head or gain access to the brain for scientific purposes. Wound management that promotes healing after the cranial implant surgery in non-human primates can be difficult as it is not necessarily possible to cover the wound margins. Here, we developed an easily modifiable head cap that protects the sutured skin margins after cranial implant surgery and contributes to wound healing. The protective head cap was developed in response to monkeys picking at sutured skin margins around an implant, complicating healing. The user-friendly protective cap, made from Klarity- R™ Sheet (3.2 mm thick with 36 % or 42 % perforation) is affixed to the implant post-surgically. Once secured and while the monkey is still anesthetized, the plastic sheeting is molded around the implant. The protective head cap restricts the monkey's finger access to its' wound margins while allowing air to circulate to promote wound healing. Across two UK primate facilities, the protective head cap promoted wound healing. In monkeys that did not wear the head cap, re-suturing was necessary in ∼30 % of cases. In contrast, none of the monkeys that wore the head cap required re-suturing. The monkeys wearing the head cap also had reduced numbers of days of prescribed antibiotics and analgesia. This bespoken, easily adaptable, protective head cap supports postoperative wound healing, and enhances the welfare of monkeys involved in neuroscience research.

Neuroimaging

Wound management

Neuroscience

Welfare

Non-human primate

Cognition

Macaca mulatta

Behavior

Primate chair

Neurophysiology

Details

Title: Subtitle: Protective cranial implant caps for macaques
Creators: Brook A L Perry - University of Oxford
Stuart Mason - University of Oxford
Jennifer Nacef - Newcastle University
Ashley Waddle - Newcastle University
Brian Hynes - Hybex Innovations Inc., 9851 Boulevard Parkway, Anjou, Quebec, H1J 1P3, Canada.
Caroline Bergmann - University of Oxford
Michael C Schmid - University of Fribourg
Christopher I Petkov - University of Newcastle Australia
Alexander Thiele - Newcastle University
Anna S Mitchell - University of Oxford
Resource Type: Journal article
Publication Details: Journal of neuroscience methods, Vol.348, pp.108992-108992
DOI: 10.1016/j.jneumeth.2020.108992
PMID: 33130051
PMCID: PMC7840592
NLM abbreviation: J Neurosci Methods
ISSN: 0165-0270
eISSN: 1872-678X
Grant note: MR/P013031/1 / Medical Research Council Wellcome Trust WT093104 / Wellcome Trust 110157/Z/15/Z / Wellcome Trust WT092606AIA / Wellcome Trust
Language: English
Date published: 01/15/2021
Academic Unit: Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984360130602771

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