Journal article
Protective effect of diethylmaleate pretreatment on carbon tetrachloride hepatotoxicity
Toxicology and applied pharmacology, Vol.57(3), pp.318-324
1981
DOI: 10.1016/0041-008X(81)90232-5
PMID: 7222046
Abstract
The administration of diethylmaleate (DEM) to fed and fasted rats produced a marked depletion of hepatic reduced glutathione (GSH) to 26 and 20% of respective saline control values 30 min after drug administration. When carbon tetrachloride (CCl
4) was administered to fasted animals pretreated with saline or DEM, the serum enzymes GOT, GPT, and ICDH were elevated 24 hr after intoxication, but the increases were greater in the saline-pretreated group (
p < 0.05). The administration of CCl
4 to fed animals produced elevations in serum GOT, GPT, and ICDH 24 hr after intoxication that were of similar magnitude in the saline- and DEM-pretreated groups (
p > 0.05). CCl
4 administration to fed rats produced altered hepatocellular architecture that was of similar magnitude in saline- and DEM-pretreated animals. However, in fasted animals, the histological changes following CCl
4 administration were more severe in saline-pretreated animals when compared to the DEM-pretreated group. The data suggest that DEM pretreatment exerts a protective effect against CCl
4-induced hepatic injury in fasted rats that may be related to the ability of DEM to inhibit hepatic microsomal drug metabolism.
Details
- Title: Subtitle
- Protective effect of diethylmaleate pretreatment on carbon tetrachloride hepatotoxicity
- Creators
- K.A SuarezK GriffinR.P KopplinP Bhonsle
- Resource Type
- Journal article
- Publication Details
- Toxicology and applied pharmacology, Vol.57(3), pp.318-324
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0041-008X(81)90232-5
- PMID
- 7222046
- ISSN
- 0041-008X
- eISSN
- 1096-0333
- Language
- English
- Date published
- 1981
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984094490502771
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