Journal article
Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice
Journal of physiology and biochemistry, Vol.69(3), pp.513-525
09/01/2013
DOI: 10.1007/s13105-013-0240-0
PMID: 23385671
Abstract
Doxorubicin (DOX), a potent chemotherapeutic agent, is widely used for the treatment of various malignancies. However, its clinical uses are limited due to its dose-dependent adverse effects particularly cardiac and testicular toxicities. DOX-induced toxicity is mainly due to the induction of oxidative stress. Atorvastatin (ATV), a 3-hydroxy 3-methyl glutaryl coenzyme A reductase inhibitor, with lipid-lowering activity, acts as an antioxidant at lower doses. It possesses pleiotropic effects independent of cholesterol-lowering property usually shown at lower doses, which include antioxidant and anti-inflammatory activities. The present study was aimed to investigate the possible protection exerted by atorvastatin against oxidative stress and DNA damage induced by DOX in the heart and testes of mice. The protective role of ATV in the heart and testes of DOX-treated mice was evident from the amelioration of oxidative stress, DNA and cellular damage. The present study clearly indicates that ATV offers a significant protection against DOX-induced oxidative stress and DNA damage in the heart and testes of mice.
Details
- Title: Subtitle
- Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice
- Creators
- S. V. V. S. Ramanjaneyulu - Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Facil Risk Assessment & Intervent Studies, Sas Nagar 160062, Punjab, IndiaP. P. Trivedi - National Institute of Pharmaceutical Education and ResearchS. Kushwaha - National Institute of Pharmaceutical Education and ResearchA. Vikram - University of PittsburghG. B. Jena - National Institute of Pharmaceutical Education and Research
- Resource Type
- Journal article
- Publication Details
- Journal of physiology and biochemistry, Vol.69(3), pp.513-525
- Publisher
- Servicio Publicaciones Universidad Navarra
- DOI
- 10.1007/s13105-013-0240-0
- PMID
- 23385671
- ISSN
- 1138-7548
- eISSN
- 1877-8755
- Number of pages
- 13
- Grant note
- National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar
- Language
- English
- Date published
- 09/01/2013
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984359836002771
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