Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate

Meltem Ugras; Cengiz Yakinci

doi:10.1016/j.braindev.2006.03.009

Back

Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate

Journal article

Peer reviewed

Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate

Meltem Ugras and Cengiz Yakinci

Brain & development (Tokyo. 1979), Vol.28(9), pp.549-553

10/01/2006

DOI: 10.1016/j.braindev.2006.03.009

PMID: 16842952

View Online

Abstract

This study was conducted to evaluate some anticoagulants' (protein C, protein S and antithrombin) activities among epileptic children treated with VPA and to learn if thromboembolic events occur among these children or their parents. Twenty-five boys and 15 girls using VPA for at least 3 months were included in the VPA group. The control group consisted of 28 boys and 12 girls who had no infection and did not use any medication that could alter protein C activity. Complete blood counts, ALT, AST, PT, aPTT, fibrinogen, protein C, protein S and AT tests were studied in both groups. Serum VPA levels were determined in the VPA group. Protein C and protein S activities of the children in the VPA group were significantly lower than those in the control group (89.5+/-19.3% vs 104.9+/-21.7% and 44.6+/-16.3% vs 59.4+/-28.4%, respectively). Neither children using VPA, nor their parents had any thromboembolic events in medical history. Platelet counts, ALT and fibrinogen levels in the VPA group were significantly lower than those in the controls. A negative correlation was found between serum VPA level and platelet counts. There were also negative correlations between fibrinogen and serum VPA levels, and between fibrinogen level and protein S activity. The children in the VPA group had lower PT and higher aPTT levels than the children in the control group. Since other factors known to alter the anticoagulant activities and liver functions were eliminated initially, the decreases of protein C and protein S activities, thrombocyte counts, ALT, PT and fibrinogen levels and increase in aPTT level may be attributed to VPA. VPA hepatotoxicity can be the cause of decreased pro- and anticoagulant activities.

Adolescent

Anticoagulants - metabolism

Anticonvulsants - blood

Anticonvulsants - pharmacology

Anticonvulsants - therapeutic use

Blood Cell Count - methods

Case-Control Studies

Child

Child, Preschool

Enzyme Activation - drug effects

Epilepsy - blood

Epilepsy - drug therapy

Female

Fibrinogen - metabolism

Humans

Infant

Male

Protein C - metabolism

Protein S - metabolism

Retrospective Studies

Statistics, Nonparametric

Valproic Acid - blood

Valproic Acid - pharmacology

Valproic Acid - therapeutic use

Details

Title: Subtitle: Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate
Creators: Meltem Ugras - Inonu University
Cengiz Yakinci
Resource Type: Journal article
Publication Details: Brain & development (Tokyo. 1979), Vol.28(9), pp.549-553
DOI: 10.1016/j.braindev.2006.03.009
PMID: 16842952
NLM abbreviation: Brain Dev
ISSN: 0387-7604
Language: English
Date published: 10/01/2006
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9985214169102771

Metrics

1 Record Views

8 Times Cited - Web of Science