Journal article
Protein Ionizable Groups: pK Values and Their Contribution to Protein Stability and Solubility
The Journal of biological chemistry, Vol.284(20), pp.13285-13289
05/15/2009
DOI: 10.1074/jbc.R800080200
PMCID: PMC2679426
PMID: 19164280
Abstract
The structure, stability, solubility, and function of proteins depend on
their net charge and on the ionization state of the individual residues.
Consequently, biochemists are interested in the p
K
values of the
ionizable groups in proteins and how these p
K
values depend on their
environment. We review what has been learned about p
K
values of
ionizable groups in proteins from experimental studies and discuss the
important contributions they make to protein stability and solubility.
Details
- Title: Subtitle
- Protein Ionizable Groups: pK Values and Their Contribution to Protein Stability and Solubility
- Creators
- C. Nick Pace - Texas A&M Health Science CenterGerald R. Grimsley - Texas A&M Health Science CenterJ. Martin Scholtz - Texas A&M Health Science Center
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.284(20), pp.13285-13289
- DOI
- 10.1074/jbc.R800080200
- PMID
- 19164280
- PMCID
- PMC2679426
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Publisher
- American Society for Biochemistry and Molecular Biology
- Language
- English
- Date published
- 05/15/2009
- Academic Unit
- Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Chemistry
- Record Identifier
- 9984288732102771
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