Journal article
Protein Kinase A in neurological disorders
Journal of neurodevelopmental disorders, Vol.16(1), 9
03/13/2024
DOI: 10.1186/s11689-024-09525-0
PMCID: PMC10936040
PMID: 38481146
Abstract
Cyclic adenosine 3', 5' monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of physiological processes including gene transcription, metabolism, and synaptic plasticity. Genomic sequencing studies have identified both germline and somatic variants of the catalytic and regulatory subunits of PKA in patients with metabolic and neurodevelopmental disorders. In this review we discuss the classical cAMP/PKA signaling pathway and the disease phenotypes that result from PKA variants. This review highlights distinct isoform-specific cognitive deficits that occur in both PKA catalytic and regulatory subunits, and how tissue-specific distribution of these isoforms may contribute to neurodevelopmental disorders in comparison to more generalized endocrine dysfunction.
Details
- Title: Subtitle
- Protein Kinase A in neurological disorders
- Creators
- Alexander G P Glebov-McCloud - University of IowaWalter S Saide - University of IowaMarie E Gaine - University of IowaStefan Strack - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurodevelopmental disorders, Vol.16(1), 9
- DOI
- 10.1186/s11689-024-09525-0
- PMID
- 38481146
- PMCID
- PMC10936040
- ISSN
- 1866-1947
- eISSN
- 1866-1955
- Grant note
- R21 AG080472 / NIA NIH HHS T32 GM144636 / NIGMS NIH HHS T32 NS045549 / NINDS NIH HHS T32GM144636 / NIGMS NIH HHS T32NS045549 / NINDS NIH HHS AG080472-01 / NIA NIH HHS
- Language
- English
- Date published
- 03/13/2024
- Academic Unit
- Psychiatry; Pathology; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984572458702771
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