Journal article
Protein binding of vancomycin in a patient with immunoglobulin A myeloma
Antimicrobial agents and chemotherapy, Vol.34(7), pp.1459-1461
07/1990
DOI: 10.1128/AAC.34.7.1459
PMCID: PMC176003
PMID: 2386376
Abstract
Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.
Details
- Title: Subtitle
- Protein binding of vancomycin in a patient with immunoglobulin A myeloma
- Creators
- Thomas G Cantú - Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205James D Dick - Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205David E Elliott - Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205Richard L Humphrey - Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205David M Kornhauser - Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.34(7), pp.1459-1461
- DOI
- 10.1128/AAC.34.7.1459
- PMID
- 2386376
- PMCID
- PMC176003
- NLM abbreviation
- Antimicrob Agents Chemother
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 07/1990
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094872702771
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