Journal article
Protein mixed-disulfides in cardiac cells. S-thiolation of soluble proteins in response to diamide
Biochimica et biophysica acta. Molecular cell research, Vol.844(1), pp.50-54
01/18/1985
DOI: 10.1016/0167-4889(85)90232-0
PMID: 3967051
Abstract
Protein mixed-disulfides in cultured rat heart cells were analyzed by gel electrophoresis under conditions that eliminated artifactual formation of these protein derivatives. Protein S-thiolation (protein mixed-disulfide formation) was detectable under normal culture conditions. Diamide oxidized intracellular glutathione in these cells and produced extensive protein S-thiolation. The specificity of this protein modification indicates a role in the regulation of cardiac metabolism.
Details
- Title: Subtitle
- Protein mixed-disulfides in cardiac cells. S-thiolation of soluble proteins in response to diamide
- Creators
- Linda M GrimmMark W CollisonRory A FisherJames A Thomas
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Molecular cell research, Vol.844(1), pp.50-54
- Publisher
- Netherlands
- DOI
- 10.1016/0167-4889(85)90232-0
- PMID
- 3967051
- ISSN
- 1879-2596
- eISSN
- 0167-4889
- Grant note
- HL-13630 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/18/1985
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040543902771
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