Journal article
Protein sorting, targeting and trafficking in photoreceptor cells
Progress in retinal and eye research, Vol.36, pp.24-51
09/2013
DOI: 10.1016/j.preteyeres.2013.03.002
PMCID: PMC3759535
PMID: 23562855
Abstract
Vision is the most fundamental of our senses initiated when photons are absorbed by the rod and cone photoreceptor neurons of the retina. At the distal end of each photoreceptor resides a light-sensing organelle, called the outer segment, which is a modified primary cilium highly enriched with proteins involved in visual signal transduction. At the proximal end, each photoreceptor has a synaptic terminal, which connects this cell to the downstream neurons for further processing of the visual information. Understanding the mechanisms involved in creating and maintaining functional compartmentalization of photoreceptor cells remains among the most fascinating topics in ocular cell biology. This review will discuss how photoreceptor compartmentalization is supported by protein sorting, targeting and trafficking, with an emphasis on the best-studied cases of outer segment-resident proteins.
Details
- Title: Subtitle
- Protein sorting, targeting and trafficking in photoreceptor cells
- Creators
- Jillian N Pearring - Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USARaquel Y Salinas - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USASheila A Baker - Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USAVadim Y Arshavsky - Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
- Resource Type
- Journal article
- Publication Details
- Progress in retinal and eye research, Vol.36, pp.24-51
- DOI
- 10.1016/j.preteyeres.2013.03.002
- PMID
- 23562855
- PMCID
- PMC3759535
- NLM abbreviation
- Prog Retin Eye Res
- ISSN
- 1350-9462
- eISSN
- 1873-1635
- Publisher
- Elsevier Ltd
- Grant note
- name: NIH, award: EY022508, EY022862, EY020542, EY010336, EY012859, EY05722; DOI: 10.13039/100001818, name: Research to Prevent Blindness
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Iowa Neuroscience Institute; Biochemistry and Molecular Biology; University College Courses; Ophthalmology and Visual Sciences
- Record Identifier
- 9984024415902771
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