Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment

Gabriel Velez; C Nathaniel Roybal; Elaine Binkley; Alexander G Bassuk; Stephen H Tsang; Vinit B Mahajan

doi:10.1016/j.ajoc.2016.12.023

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Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment

Journal article

Open access

Peer reviewed

Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment

Gabriel Velez, C Nathaniel Roybal, Elaine Binkley, Alexander G Bassuk, Stephen H Tsang and Vinit B Mahajan

American journal of ophthalmology case reports, Vol.5(C), pp.107-110

04/2017

DOI: 10.1016/j.ajoc.2016.12.023

PMCID: PMC5560621

PMID: 28825049

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https://doi.org/10.1016/j.ajoc.2016.12.023View

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Abstract

To report a case of elevated intraocular pressure with retinal detachment. Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology. Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.

intraocular pressure

retinal detachment

Proteomics

Details

Title: Subtitle: Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment
Creators: Gabriel Velez - Medical Scientist Training Program, University of Iowa, Iowa City, IA
C Nathaniel Roybal - Departments of Ophthalmology, University of Iowa, Iowa City, IA
Elaine Binkley - Departments of Ophthalmology, University of Iowa, Iowa City, IA
Alexander G Bassuk - Department of Neurology, University of Iowa, Iowa City, IA
Stephen H Tsang - Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032
Vinit B Mahajan - Departments of Ophthalmology, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: American journal of ophthalmology case reports, Vol.5(C), pp.107-110
DOI: 10.1016/j.ajoc.2016.12.023
PMID: 28825049
PMCID: PMC5560621
NLM abbreviation: Am J Ophthalmol Case Rep
ISSN: 2451-9936
eISSN: 2451-9936
Publisher: United States
Grant note: R01 EY024665 / NEI NIH HHS T32 GM007337 / NIGMS NIH HHS K08 EY020530 / NEI NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Ophthalmology and Visual Sciences
Record Identifier: 9984070404902771

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