Journal article
Proteomic profiling identifies biomarkers of COVID-19 severity
Heliyon, Vol.10(1), e23320
01/01/2024
DOI: 10.1016/j.heliyon.2023.e23320
PMCID: PMC10755324
PMID: 38163173
Abstract
SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including mesothelin (MSLN), that are expressed at significantly higher levels in severe COVID-19 subjects. In addition, we find a subset of markers associated with T-cell and dendritic cell responses to viral infection that are significantly higher in mild cases and decrease in expression as severity of COVID-19 increases, suggesting that an immediate and effective activation of T-cells is critical in modulating disease progression. Together, our findings identify new targets for further investigation as therapeutic approaches for the treatment of SARS-CoV-2 infection and prevention of complications of severe COVID-19.
Details
- Title: Subtitle
- Proteomic profiling identifies biomarkers of COVID-19 severity
- Creators
- Noa C. HarriottAmy L. Ryan
- Resource Type
- Journal article
- Publication Details
- Heliyon, Vol.10(1), e23320
- Publisher
- Elsevier
- DOI
- 10.1016/j.heliyon.2023.e23320
- PMID
- 38163173
- PMCID
- PMC10755324
- eISSN
- 2405-8440
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984531960302771
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