Journal article
Proteomics studies in inner ear disorders: pathophysiology and biomarkers
Expert review of proteomics, Vol.12(2), pp.185-196
04/01/2015
DOI: 10.1586/14789450.2015.1024228
PMID: 25795149
Abstract
Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are underused due to technical challenges and/or complex features of the disease. Thus, in the past few years, healthcare and scientific agencies have advocated the development and adoption of proteomic technologies in otological research. However, few studies have been conducted and limited literature is available in this area. Here, we present the state of the art of proteomics in otology, discussing the substantial evidence from recent experimental models and clinical studies in inner-ear conditions. We also delineate a series of critical issues including minute size of the inner ear, delicacy and poor accessibility of tissue that researchers face while undertaking otology proteomics research. Furthermore, we provide perspective to enhance the impact and lead to the clinical implementation of these proteomics-based strategies.
Details
- Title: Subtitle
- Proteomics studies in inner ear disorders: pathophysiology and biomarkers
- Creators
- Ali Alawieh - American University of BeirutStefania Mondello - University of MessinaFiras Kobeissy - American University of BeirutKamel Shibbani - American University of BeirutMarc Bassim - American University of Beirut
- Resource Type
- Journal article
- Publication Details
- Expert review of proteomics, Vol.12(2), pp.185-196
- Publisher
- Taylor & Francis
- DOI
- 10.1586/14789450.2015.1024228
- PMID
- 25795149
- ISSN
- 1478-9450
- eISSN
- 1744-8387
- Number of pages
- 12
- Language
- English
- Date published
- 04/01/2015
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984702946802771
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