Protocadherins branch out: Multiple roles in dendrite development

Austin B Keeler; Michael J Molumby; Joshua A Weiner

doi:10.1080/19336918.2014.1000069

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Protocadherins branch out: Multiple roles in dendrite development

Journal article

Open access

Peer reviewed

Protocadherins branch out: Multiple roles in dendrite development

Austin B Keeler, Michael J Molumby and Joshua A Weiner

Cell adhesion & migration, Vol.9(3), pp.214-226

05/04/2015

DOI: 10.1080/19336918.2014.1000069

PMCID: PMC4594470

PMID: 25869446

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Abstract

The proper formation of dendritic arbors is a critical step in neural circuit formation, and as such defects in arborization are associated with a variety of neurodevelopmental disorders. Among the best gene candidates are those encoding cell adhesion molecules, including members of the diverse cadherin superfamily characterized by distinctive, repeated adhesive domains in their extracellular regions. Protocadherins (Pcdhs) make up the largest group within this superfamily, encompassing over 80 genes, including the ∼60 genes of the α-, β-, and γ-Pcdh gene clusters and the non-clustered δ-Pcdh genes. An additional group includes the atypical cadherin genes encoding the giant Fat and Dachsous proteins and the 7-transmembrane cadherins. In this review we highlight the many roles that Pcdhs and atypical cadherins have been demonstrated to play in dendritogenesis, dendrite arborization, and dendritic spine regulation. Together, the published studies we discuss implicate these members of the cadherin superfamily as key regulators of dendrite development and function, and as potential therapeutic targets for future interventions in neurodevelopmental disorders.

arborization

Pcdh

cadherin superfamily

dendritogenesis

atypical cadherin

cell adhesion

neural circuit formation

dendritic spine

self avoidance

dendritic

branching

synaptogenesis

Details

Title: Subtitle: Protocadherins branch out: Multiple roles in dendrite development
Creators: Austin B Keeler - Department of Biology; Neuroscience Graduate Program; University of Iowa
Michael J Molumby - Department of Biology; Genetics Graduate Program; University of Iowa
Joshua A Weiner - Department of Biology and Department of Psychiatry; The University of Iowa
Resource Type: Journal article
Publication Details: Cell adhesion & migration, Vol.9(3), pp.214-226
DOI: 10.1080/19336918.2014.1000069
PMID: 25869446
PMCID: PMC4594470
NLM abbreviation: Cell Adh Migr
ISSN: 1933-6918
eISSN: 1933-6926
Publisher: Taylor & Francis
Language: English
Date published: 05/04/2015
Academic Unit: Liberal Arts and Science Admin; Psychiatry; Iowa Neuroscience Institute; Biology
Record Identifier: 9983997424802771

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