Journal article
Protocols for multi-site trials using hyperpolarized Xe-129 MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the Xe-129 MRI clinical trials consortium
Magnetic resonance in medicine, Vol.86(6), pp.2966-2986
12/01/2021
DOI: 10.1002/mrm.28985
PMID: 34478584
Abstract
Hyperpolarized (HP) Xe-129 MRI uniquely images pulmonary ventilation, gas exchange, and terminal airway morphology rapidly and safely, providing novel information not possible using conventional imaging modalities or pulmonary function tests. As such, there is mounting interest in expanding the use of biomarkers derived from HP Xe-129 MRI as outcome measures in multi-site clinical trials across a range of pulmonary disorders. Until recently, HP Xe-129 MRI techniques have been developed largely independently at a limited number of academic centers, without harmonizing acquisition strategies. To promote uniformity and adoption of HP Xe-129 MRI more widely in translational research, multi-site trials, and ultimately clinical practice, this position paper from the Xe-129 MRI Clinical Trials Consortium (https://cpir.cchmc.org/XeMRICTC) recommends standard protocols to harmonize methods for image acquisition in HP Xe-129 MRI. Recommendations are described for the most common HP gas MRI techniques-calibration, ventilation, alveolar-airspace size, and gas exchange-across MRI scanner manufacturers most used for this application. Moreover, recommendations are described for Xe-129 dose volumes and breath-hold standardization to further foster consistency of imaging studies. The intention is that sites with HP Xe-129 MRI capabilities can readily implement these methods to obtain consistent high-quality images that provide regional insight into lung structure and function. While this document represents consensus at a snapshot in time, a roadmap for technical developments is provided that will further increase image quality and efficiency. These standardized dosing and imaging protocols will facilitate the wider adoption of HP Xe-129 MRI for multi-site pulmonary research.
Details
- Title: Subtitle
- Protocols for multi-site trials using hyperpolarized Xe-129 MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the Xe-129 MRI clinical trials consortium
- Creators
- Peter J. Niedbalski - University of Kansas Medical CenterChase S. Hall - University of Kansas Medical CenterMario Castro - University of Kansas Medical CenterRachel L. Eddy - University of British ColumbiaJonathan H. Rayment - University of British ColumbiaSarah Svenningsen - McMaster UniversityGrace Parraga - Robarts Research InstituteBrandon Zanette - Hospital for Sick ChildrenGiles E. Santyr - University of TorontoRobert P. Thomen - University of MissouriNeil J. Stewart - University of SheffieldGuilhem J. Collier - University of SheffieldHo-Fung Chan - University of SheffieldJim M. Wild - University of SheffieldSean B. Fain - University of Wisconsin–MadisonG. Wilson Miller - University of VirginiaJaime F. Mata - University of VirginiaJohn P. Mugler - University of VirginiaBastiaan Driehuys - Duke UniversityMatthew M. Willmering - Cincinnati Children's Hospital Medical CenterZackary Cleveland - Cincinnati Children's Hospital Medical CenterJason C. Woods - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.86(6), pp.2966-2986
- Publisher
- Wiley
- DOI
- 10.1002/mrm.28985
- PMID
- 34478584
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 21
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984275057002771
Metrics
18 Record Views