Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research

Joseph J Shaffer Jr; Merry Mani; Samantha L Schmitz; Jia Xu; Nana Owusu; Dee Wu; Vincent A Magnotta; John A Wemmie

doi:10.3389/fpsyt.2020.532606

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Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research

Journal article

Open access

Peer reviewed

Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research

Joseph J Shaffer Jr, Merry Mani, Samantha L Schmitz, Jia Xu, Nana Owusu, Dee Wu, Vincent A Magnotta and John A Wemmie

Frontiers in psychiatry, Vol.11, pp.532606-532606

2020

DOI: 10.3389/fpsyt.2020.532606

PMCID: PMC7542226

PMID: 33192650

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Abstract

Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation transfer (CEST) and T1 relaxation in the rotating frame (T1ρ), are emerging as promising tools in the study of neurological and psychiatric illnesses to study brain metabolism. This review describes proton exchange for non-experts, highlights the current status of proton-exchange MRI, and presents advantages and drawbacks of these techniques compared to more traditional methods of imaging brain metabolism, including positron emission tomography (PET) and MR spectroscopy (MRS). Finally, this review highlights new frontiers for the use of CEST and T1ρ in brain research.

Neuroimaging

psychiatric disorders and mental health

chemical exchange saturation transfer (CEST) imaging

proton exchange

T1ρ MRI

Details

Title: Subtitle: Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research
Creators: Joseph J Shaffer Jr - Department of Radiology, University of Iowa, Iowa City, IA, United States
Merry Mani - Department of Radiology, University of Iowa, Iowa City, IA, United States
Samantha L Schmitz - Department of Psychiatry, University of Iowa, Iowa City, IA, United States
Jia Xu - Department of Radiology, University of Iowa, Iowa City, IA, United States
Nana Owusu - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States
Dee Wu - Department of Radiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Vincent A Magnotta - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States
John A Wemmie - Department of Neurosurgery, University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Frontiers in psychiatry, Vol.11, pp.532606-532606
DOI: 10.3389/fpsyt.2020.532606
PMID: 33192650
PMCID: PMC7542226
NLM abbreviation: Front Psychiatry
ISSN: 1664-0640
eISSN: 1664-0640
Publisher: Switzerland
Grant note: R01 EB022019 / NIBIB NIH HHS S10 RR028821 / NCRR NIH HHS R01 MH111578 / NIMH NIH HHS
Language: English
Date published: 2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984066388502771

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