Journal article
Proton MR spectroscopic features of the cisternal segment of the trigeminal nerve in patients with trigeminal neuralgia: A pilot study
Clinical imaging, Vol.74, pp.93-99
06/2021
DOI: 10.1016/j.clinimag.2020.12.006
PMID: 33465667
Abstract
To investigate normal quantitative proton magnetic resonance spectroscopy (MRS) features of the cisternal segment of the trigeminal nerve and evaluate possible metabolite concentration differences in the affected and unaffected nerves of trigeminal neuralgia patients.
A total of 33 consecutive patients who underwent a MR study of the internal auditory canal/posterior fossa and dedicated trigeminal nerve multivoxel MRS were enrolled. Measurements of N-acetyl aspartate (NAA), creatine (Cr), choline (Cho), myoinositol (mI), glutamate-glutamine (Glx) concentrations, and ratios of NAA-to-Cr, Cho-to-Cr, and Cho-to-NAA were automatically calculated by the dedicated software. Vascular conflicts were also recorded.
The mean Cr concentration was significantly higher on the affected sides in all parts of the nerve (p < 0.05), while the mean NAA concentration was significantly higher in only the distal portion (p = 0.04). Mean mI concentration was significantly higher in the middle and distal parts (p < 0.05). NAA-to-Cr ratio was significantly higher in the proximal and middle parts (p < 0.05), while Cho-to-Cr ratio was significantly higher only in the middle portion (p = 0.028). Finally, the Cho-to-NAA ratio was significantly higher only in the distal portion (p = 0.04). Vascular conflicts were observed in 24 patients (72.7%), and in 20 of them (60.6%) the conflict was on the same side as the neuralgia symptoms.
Although the detected statistical relationships were variable in the spectroscopic measurements, metabolite concentrations and ratios were successfully exhibited in all patients. Features of a normal trigeminal nerve were able to determine by MRS. All calculated metabolite concentrations were higher in the affected nerves; however, only some of them were statistically significant. No statistically significant relationships were found between the MRS measurements and nerves with and without vascular compression.
•High-quality MR spectroscopy images can be obtained from trigeminal nerve by using a dedicated software at 3.0 Tesla system.•Automatically calculated concentrations were higher in the affected nerves; but, only some showed statistical significance.•The calculated metabolite ratios were variable in the affected and unaffected trigeminal nerves.•No significant difference was found regarding MR spectroscopic measurements in nerves with and without vascular compression.
Details
- Title: Subtitle
- Proton MR spectroscopic features of the cisternal segment of the trigeminal nerve in patients with trigeminal neuralgia: A pilot study
- Creators
- Kemal Niyazi Arda - Sağlık Bilimleri ÜniversitesiSinan Akay - Sağlık Bilimleri ÜniversitesiOmer Karadas - Sağlık Bilimleri ÜniversitesiOmer Kartal - Ankara University
- Resource Type
- Journal article
- Publication Details
- Clinical imaging, Vol.74, pp.93-99
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.clinimag.2020.12.006
- PMID
- 33465667
- ISSN
- 0899-7071
- eISSN
- 1873-4499
- Number of pages
- 7
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984702943102771
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