Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium

Jeffrey R YAGER; Vincent A MAGNOTTA; James A MILLS; Stacie M VIK; Michelle T WECKMANN; Aristides A CAPIZZANO; Roger GINGRICH; Leigh J BEGLINGER

doi:10.1016/j.pscychresns.2010.11.003

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Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium

Journal article

Open access

Peer reviewed

Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium

Jeffrey R YAGER, Vincent A MAGNOTTA, James A MILLS, Stacie M VIK, Michelle T WECKMANN, Aristides A CAPIZZANO, Roger GINGRICH and Leigh J BEGLINGER

Psychiatry research. Neuroimaging, Vol.191(2), pp.128-132

2011

DOI: 10.1016/j.pscychresns.2010.11.003

PMCID: PMC3030637

PMID: 21227658

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https://www.ncbi.nlm.nih.gov/pmc/articles/3030637View

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Abstract

Delirium is associated with a host of negative outcomes, including increased risk of mortality, longer hospital stay, and poor long-term cognitive function. The pathophysiology of delirium is not well understood. Cancer patients undergoing a bone marrow transplant (BMT) are at high risk for developing delirium and Proton Magnetic Resonance Spectroscopy ((1)H MRS) could lead to better understanding of the delirium process. Fourteen BMT patients and 10 controls completed (1)H MRS, positioned above the corpus callosum, shortly after delirium onset or at study end if no delirium occurred. In the BMT-delirium group, statistically significantly elevated tCho/tCr was found in contrast to the BMT-no delirium group. The BMT-delirium group also showed statistically significantly lesser NAA/tCho compared with both controls and the BMT-no delirium group. Elevated choline and reduced NAA indicate inflammatory processes and white matter damage as well as neuronal metabolic impairment. Further research is needed to separate the choline peaks, as well as more detailed collection of medication regimens to determine whether a higher choline concentration is a function of the delirium process or cancer treatment effects.

Organic mental disorders. Neuropsychology

Biological and medical sciences

Psychology. Psychoanalysis. Psychiatry

Medical sciences

Adult and adolescent clinical studies

Psychopathology. Psychiatry

Details

Title: Subtitle: Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium
Creators: Jeffrey R YAGER - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Vincent A MAGNOTTA - University of Iowa Carver College of Medicine, Iowa City, IA, United States
James A MILLS - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Stacie M VIK - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Michelle T WECKMANN - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Aristides A CAPIZZANO - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Roger GINGRICH - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Leigh J BEGLINGER - University of Iowa Carver College of Medicine, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.191(2), pp.128-132
DOI: 10.1016/j.pscychresns.2010.11.003
PMID: 21227658
PMCID: PMC3030637
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Publisher: Elsevier; Shannon
Language: English
Date published: 2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Family and Community Medicine; Internal Medicine
Record Identifier: 9984025279402771

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