Journal article
Proton T1ρ-dispersion imaging of rodent brain at 1.9 T
Journal of magnetic resonance imaging, Vol.8(5), pp.1090-1096
09/1998
DOI: 10.1002/jmri.1880080514
PMID: 9786147
Abstract
Detection of H2(17)O with proton T1rho-dispersion imaging holds promise as a means of quantifying metabolism and blood flow with MRI. However, this technique requires a priori knowledge of the intrinsic T1rho dispersion of tissue. To investigate these properties, we implemented a T1rho imaging sequence on a 1.9-T Signa GE scanner. A series of T1rho images for different locking frequencies and locking durations were obtained from rat brain in vivo and compared with 5% (wt/vol) gelatin phantoms containing different concentrations of (17)O ranging from .037% (natural abundance) to 2.0 atom%. Results revealed that, although there is considerable T1rho-dispersion in phantoms doped with H2(17)O, the T1rho of rat brain undergoes minimal dispersion for spin-locking frequencies between .2 and 1.5 kHz. A small degree of T1rho dispersion is present below .2 kHz, which we postulate arises from natural-abundance H2(17)O. Moreover, the signal-to-noise ratios of T1rho-weighted images are significantly better than comparable T2-weighted images, allowing for improved visualization of tissue contrast. We have also demonstrated the feasibility of proton T1rho-dispersion imaging for detecting intravenous H2(17)O on a live mouse brain. The potential application of this technique to study brain perfusion is discussed.
Details
- Title: Subtitle
- Proton T1ρ-dispersion imaging of rodent brain at 1.9 T
- Creators
- Rahim R Rizi - Metabolic Magnetic Resonance and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia 19104-6100, USASridhar R CharagundlaHee Kwon SongRavinder ReddyAlan H StolpenMitchell D SchnallJohn S Leigh
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.8(5), pp.1090-1096
- Publisher
- United States
- DOI
- 10.1002/jmri.1880080514
- PMID
- 9786147
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Grant note
- R29-NS-35625 / NINDS NIH HHS RR-02305 / NCRR NIH HHS
- Language
- English
- Date published
- 09/1998
- Academic Unit
- Radiology; Internal Medicine
- Record Identifier
- 9984051551102771
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