Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla

Stefan Posse; Ricardo Otazo; Arvind Caprihan; Juan Bustillo; Hongji Chen; Pierre-Gilles Henry; Malgorzata Marjanska; Charles Gasparovic; Chun Zuo; Vincent Magnotta; Bryon Mueller; Paul Mullins; Perry Renshaw; Kamil Ugurbil; Kelvin O Lim; Jeffry R Alger

doi:10.1002/mrm.21287

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Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla

Journal article

Open access

Peer reviewed

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla

Stefan Posse, Ricardo Otazo, Arvind Caprihan, Juan Bustillo, Hongji Chen, Pierre-Gilles Henry, Malgorzata Marjanska, Charles Gasparovic, Chun Zuo, Vincent Magnotta, …

Magnetic resonance in medicine, Vol.58(2), pp.236-244

08/2007

DOI: 10.1002/mrm.21287

PMID: 17610279

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Abstract

In this multicenter study, 2D spatial mapping of J-coupled resonances at 3T and 4T was performed using short-TE (15 ms) proton echo-planar spectroscopic imaging (PEPSI). Water-suppressed (WS) data were acquired in 8.5 min with 1-cm(3) spatial resolution from a supraventricular axial slice. Optimized outer volume suppression (OVS) enabled mapping in close proximity to peripheral scalp regions. Constrained spectral fitting in reference to a non-WS (NWS) scan was performed with LCModel using correction for relaxation attenuation and partial-volume effects. The concentrations of total choline (tCho), creatine + phosphocreatine (Cr+PCr), glutamate (Glu), glutamate + glutamine (Glu+Gln), myo-inositol (Ins), NAA, NAA+NAAG, and two macromolecular resonances at 0.9 and 2.0 ppm were mapped with mean Cramer-Rao lower bounds (CRLBs) between 6% and 18% and approximately 150-cm(3) sensitive volumes. Aspartate, GABA, glutamine (Gln), glutathione (GSH), phosphoethanolamine (PE), and macromolecules (MMs) at 1.2 ppm were also mapped, although with larger mean CRLBs between 30% and 44%. The CRLBs at 4T were 19% lower on average as compared to 3T, consistent with a higher signal-to-noise ratio (SNR) and increased spectral resolution. Metabolite concentrations were in the ranges reported in previous studies. Glu concentration was significantly higher in gray matter (GM) compared to white matter (WM), as anticipated. The short acquisition time makes this methodology suitable for clinical studies.

Magnetic Resonance Spectroscopy - methods

Image Processing, Computer-Assisted

Humans

Middle Aged

Sensitivity and Specificity

Signal Processing, Computer-Assisted

Adult

Female

Male

Brain Chemistry

Echo-Planar Imaging - methods

Brain Mapping - methods

Details

Title: Subtitle: Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla
Creators: Stefan Posse - Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA. sposse@unm.edu
Ricardo Otazo
Arvind Caprihan
Juan Bustillo
Hongji Chen
Pierre-Gilles Henry
Malgorzata Marjanska
Charles Gasparovic
Chun Zuo
Vincent Magnotta
Bryon Mueller
Paul Mullins
Perry Renshaw
Kamil Ugurbil
Kelvin O Lim
Jeffry R Alger
Resource Type: Journal article
Publication Details: Magnetic resonance in medicine, Vol.58(2), pp.236-244
Publisher: United States
DOI: 10.1002/mrm.21287
PMID: 17610279
ISSN: 0740-3194
eISSN: 1522-2594
Grant note: 1 R01 DA14178-0 / NIDA NIH HHS P41 RR08079 / NCRR NIH HHS
Language: English
Date published: 08/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984051510902771

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